This is an advanced immunology course that will focus on the mammalian immune response and, in particular, the human immune response. Special emphasis will be placed on the physiology, genetics, and regulation of immune responses. This course emphasizes the purpose and design of experiments and how their interpretation has led to current concepts in immunology. Sessions take the form of background presentation by lecturer followed by analysis of primary research articles. Participation by students in the form of discussion and inquiry is a central objective.