This course provides the fundamental principles and concepts crucial for conducting clinical assessments, differential diagnoses, and informed therapeutic decision-making. Utilizing real-life examples drawn from pathophysiology, the course effectively illustrates complex physiological concepts. Through seminars, problem-solving exercises, and case studies, students will analyze the pathophysiological rationale behind various clinical findings. Additionally, the course emphasizes the application of cultural, diversity, and equity considerations within clinical assessments, offering a comprehensive approach to understanding and addressing healthcare disparities.