[18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo

Kiran Kumar Solingapuram Sai; Xiaofei Chen; Zhe Li; Caigang Zhu; Kirtikar Shukla; Tom E. Forshaw; Hanzhi Wu; Stephen A. Vance; Buddhika Liyana Pathirannahel; Megan Madonna; Mark W. Dewhirst; Allen W. Tsang; Leslie B. Poole; Nimmi Ramanujam; S. Bruce King; Cristina M. Furdui

doi:10.1016/j.redox.2021.102218

[18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo

Kiran Kumar Solingapuram Sai
, Xiaofei Chen
, Zhe Li
, Caigang Zhu
, Kirtikar Shukla
, Tom E. Forshaw
, Hanzhi Wu
, Stephen A. Vance
, Buddhika Liyana Pathirannahel
, Megan Madonna
, Mark W. Dewhirst
, Allen W. Tsang
, Leslie B. Poole
, Nimmi Ramanujam
, S. Bruce King
, Cristina M. Furdui

Chemistry

Wake Forest University School of Medicine
Wake Forest University
Duke University
Duke University School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Redox metabolism plays essential functions in the pathology of cancer and many other diseases. While several radiotracers for imaging redox metabolism have been developed, there are no reports of radiotracers for in vivo imaging of protein oxidation. Here we take the first step towards this goal and describe the synthesis and kinetic properties of a new positron emission tomography (PET) [18F]Fluoro-DCP radiotracer for in vivo imaging of protein sulfenylation. Time course biodistribution and PET/CT studies using xenograft animal models of Head and Neck Squamous Cell Cancer (HNSCC) demonstrate its capability to distinguish between tumors with radiation sensitive and resistant phenotypes consistent with previous reports of decreased protein sulfenylation in clinical specimens of radiation resistant HNSCC. We envision further development of this technology to aid research efforts towards improving diagnosis of patients with radiation resistant tumors.

Original language	English
Article number	102218
Journal	Redox Biology
Volume	49
Issue number	Issue
DOIs	https://doi.org/10.1016/j.redox.2021.102218
State	Published - Feb 1 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Head and Neck Squamous Cell Cancer
PET imaging
Protein sulfenylation
Radiation resistance
[18F]F-DCP

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10.1016/j.redox.2021.102218

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Solingapuram Sai, K. K., Chen, X., Li, Z., Zhu, C., Shukla, K., Forshaw, T. E., Wu, H., Vance, S. A., Pathirannahel, B. L., Madonna, M., Dewhirst, M. W., Tsang, A. W., Poole, L. B., Ramanujam, N., King, S. B., & Furdui, C. M. (2022). [18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo. Redox Biology, 49(Issue), Article 102218. https://doi.org/10.1016/j.redox.2021.102218

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title = "[18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo",

abstract = "Redox metabolism plays essential functions in the pathology of cancer and many other diseases. While several radiotracers for imaging redox metabolism have been developed, there are no reports of radiotracers for in vivo imaging of protein oxidation. Here we take the first step towards this goal and describe the synthesis and kinetic properties of a new positron emission tomography (PET) [18F]Fluoro-DCP radiotracer for in vivo imaging of protein sulfenylation. Time course biodistribution and PET/CT studies using xenograft animal models of Head and Neck Squamous Cell Cancer (HNSCC) demonstrate its capability to distinguish between tumors with radiation sensitive and resistant phenotypes consistent with previous reports of decreased protein sulfenylation in clinical specimens of radiation resistant HNSCC. We envision further development of this technology to aid research efforts towards improving diagnosis of patients with radiation resistant tumors.",

keywords = "Head and Neck Squamous Cell Cancer, PET imaging, Protein sulfenylation, Radiation resistance, [18F]F-DCP",

author = "\{Solingapuram Sai\}, \{Kiran Kumar\} and Xiaofei Chen and Zhe Li and Caigang Zhu and Kirtikar Shukla and Forshaw, \{Tom E.\} and Hanzhi Wu and Vance, \{Stephen A.\} and Pathirannahel, \{Buddhika Liyana\} and Megan Madonna and Dewhirst, \{Mark W.\} and Tsang, \{Allen W.\} and Poole, \{Leslie B.\} and Nimmi Ramanujam and King, \{S. Bruce\} and Furdui, \{Cristina M.\}",

year = "2022",

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doi = "10.1016/j.redox.2021.102218",

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Solingapuram Sai, KK, Chen, X, Li, Z, Zhu, C, Shukla, K, Forshaw, TE, Wu, H, Vance, SA, Pathirannahel, BL, Madonna, M, Dewhirst, MW, Tsang, AW, Poole, LB, Ramanujam, N, King, SB & Furdui, CM 2022, '[18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo', Redox Biology, vol. 49, no. Issue, 102218. https://doi.org/10.1016/j.redox.2021.102218

TY - JOUR

T1 - [18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo

AU - Solingapuram Sai, Kiran Kumar

AU - Chen, Xiaofei

AU - Li, Zhe

AU - Zhu, Caigang

AU - Shukla, Kirtikar

AU - Forshaw, Tom E.

AU - Wu, Hanzhi

AU - Vance, Stephen A.

AU - Pathirannahel, Buddhika Liyana

AU - Madonna, Megan

AU - Dewhirst, Mark W.

AU - Tsang, Allen W.

AU - Poole, Leslie B.

AU - Ramanujam, Nimmi

AU - King, S. Bruce

AU - Furdui, Cristina M.

PY - 2022/2/1

Y1 - 2022/2/1

N2 - Redox metabolism plays essential functions in the pathology of cancer and many other diseases. While several radiotracers for imaging redox metabolism have been developed, there are no reports of radiotracers for in vivo imaging of protein oxidation. Here we take the first step towards this goal and describe the synthesis and kinetic properties of a new positron emission tomography (PET) [18F]Fluoro-DCP radiotracer for in vivo imaging of protein sulfenylation. Time course biodistribution and PET/CT studies using xenograft animal models of Head and Neck Squamous Cell Cancer (HNSCC) demonstrate its capability to distinguish between tumors with radiation sensitive and resistant phenotypes consistent with previous reports of decreased protein sulfenylation in clinical specimens of radiation resistant HNSCC. We envision further development of this technology to aid research efforts towards improving diagnosis of patients with radiation resistant tumors.

AB - Redox metabolism plays essential functions in the pathology of cancer and many other diseases. While several radiotracers for imaging redox metabolism have been developed, there are no reports of radiotracers for in vivo imaging of protein oxidation. Here we take the first step towards this goal and describe the synthesis and kinetic properties of a new positron emission tomography (PET) [18F]Fluoro-DCP radiotracer for in vivo imaging of protein sulfenylation. Time course biodistribution and PET/CT studies using xenograft animal models of Head and Neck Squamous Cell Cancer (HNSCC) demonstrate its capability to distinguish between tumors with radiation sensitive and resistant phenotypes consistent with previous reports of decreased protein sulfenylation in clinical specimens of radiation resistant HNSCC. We envision further development of this technology to aid research efforts towards improving diagnosis of patients with radiation resistant tumors.

KW - Head and Neck Squamous Cell Cancer

KW - PET imaging

KW - Protein sulfenylation

KW - Radiation resistance

KW - [18F]F-DCP

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JO - Redox Biology

JF - Redox Biology

IS - Issue

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ER -

[18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo

Abstract

UN SDGs

Keywords

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