A facile approach to prepare shell/core nanofibers for drug controlled release

Tonghe Zhu; Chunyu Yang; Sihao Chen; Wenyao Li; Jianzhong Lou; Jihu Wang

doi:10.1016/j.matlet.2015.02.120

A facile approach to prepare shell/core nanofibers for drug controlled release

Tonghe Zhu
, Chunyu Yang
, Sihao Chen
, Wenyao Li
, Jianzhong Lou
, Jihu Wang

Shanghai University of Engineering Science

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Model drug-loaded coaxial electrospun PVP@nano-biopolymers core-shell composite nanofibers were fabricated by a facile coaxial electrospinning successfully. The model drug FA, which is a kind of lipid microsphere non-steroidal anti-inflammatory drug, was shown to be successfully adsorbed in the PVP, and the formed FA/PVP/biopolymers composite nanofibers exhibit a uniform and smooth morphology. The loaded FA within the PVP/biopolymers coaxial nanofibers showed a sustained release profile. With the significantly reduced burst-release profile, the developed FA/PVP/biopolymers composite nanofibers were proposed to be a promising material in the fields of pharmaceutical science.

Original language	English
Pages (from-to)	52-54
Number of pages	3
Journal	Materials Letters
Volume	150
DOIs	https://doi.org/10.1016/j.matlet.2015.02.120
State	Published - Jul 1 2015

Keywords

Coaxial electrospinning
Membranes
Shell/core structure
Sustained release

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10.1016/j.matlet.2015.02.120

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title = "A facile approach to prepare shell/core nanofibers for drug controlled release",

abstract = "Model drug-loaded coaxial electrospun PVP@nano-biopolymers core-shell composite nanofibers were fabricated by a facile coaxial electrospinning successfully. The model drug FA, which is a kind of lipid microsphere non-steroidal anti-inflammatory drug, was shown to be successfully adsorbed in the PVP, and the formed FA/PVP/biopolymers composite nanofibers exhibit a uniform and smooth morphology. The loaded FA within the PVP/biopolymers coaxial nanofibers showed a sustained release profile. With the significantly reduced burst-release profile, the developed FA/PVP/biopolymers composite nanofibers were proposed to be a promising material in the fields of pharmaceutical science.",

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T1 - A facile approach to prepare shell/core nanofibers for drug controlled release

AU - Zhu, Tonghe

AU - Yang, Chunyu

AU - Chen, Sihao

AU - Li, Wenyao

AU - Lou, Jianzhong

AU - Wang, Jihu

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Model drug-loaded coaxial electrospun PVP@nano-biopolymers core-shell composite nanofibers were fabricated by a facile coaxial electrospinning successfully. The model drug FA, which is a kind of lipid microsphere non-steroidal anti-inflammatory drug, was shown to be successfully adsorbed in the PVP, and the formed FA/PVP/biopolymers composite nanofibers exhibit a uniform and smooth morphology. The loaded FA within the PVP/biopolymers coaxial nanofibers showed a sustained release profile. With the significantly reduced burst-release profile, the developed FA/PVP/biopolymers composite nanofibers were proposed to be a promising material in the fields of pharmaceutical science.

AB - Model drug-loaded coaxial electrospun PVP@nano-biopolymers core-shell composite nanofibers were fabricated by a facile coaxial electrospinning successfully. The model drug FA, which is a kind of lipid microsphere non-steroidal anti-inflammatory drug, was shown to be successfully adsorbed in the PVP, and the formed FA/PVP/biopolymers composite nanofibers exhibit a uniform and smooth morphology. The loaded FA within the PVP/biopolymers coaxial nanofibers showed a sustained release profile. With the significantly reduced burst-release profile, the developed FA/PVP/biopolymers composite nanofibers were proposed to be a promising material in the fields of pharmaceutical science.

KW - Coaxial electrospinning

KW - Membranes

KW - Shell/core structure

KW - Sustained release

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A facile approach to prepare shell/core nanofibers for drug controlled release

Abstract

Keywords

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