A thiol chemistry perspective on redox medicine

Tom E. Forshaw; Allen W. Tsang; Cristina M. Furdui

A thiol chemistry perspective on redox medicine

Tom E. Forshaw
, Allen W. Tsang
, Cristina M. Furdui

Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The redox regulation of protein and low molecular weight (LMW) thiols has emerged as an exciting field for discovery in biomedical research and clinical implementation. Decades of basic research of redox-regulated and redox-regulatory proteins complemented by new methodologies for characterization and functional analysis of these proteins in multicellular systems have been instrumental in advancing redox concepts in medicine. Herein we describe the basics of protein and LMW thiol redox chemistry, methods of analysis and computational integration in complex systems, along with opportunities for clinical translation.

Original language	English
Title of host publication	Unknown book
Publisher	Elsevier
State	Published - 2022

Cite this

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title = "A thiol chemistry perspective on redox medicine",

abstract = "The redox regulation of protein and low molecular weight (LMW) thiols has emerged as an exciting field for discovery in biomedical research and clinical implementation. Decades of basic research of redox-regulated and redox-regulatory proteins complemented by new methodologies for characterization and functional analysis of these proteins in multicellular systems have been instrumental in advancing redox concepts in medicine. Herein we describe the basics of protein and LMW thiol redox chemistry, methods of analysis and computational integration in complex systems, along with opportunities for clinical translation.",

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T1 - A thiol chemistry perspective on redox medicine

AU - Forshaw, Tom E.

AU - Tsang, Allen W.

AU - Furdui, Cristina M.

PY - 2022

Y1 - 2022

N2 - The redox regulation of protein and low molecular weight (LMW) thiols has emerged as an exciting field for discovery in biomedical research and clinical implementation. Decades of basic research of redox-regulated and redox-regulatory proteins complemented by new methodologies for characterization and functional analysis of these proteins in multicellular systems have been instrumental in advancing redox concepts in medicine. Herein we describe the basics of protein and LMW thiol redox chemistry, methods of analysis and computational integration in complex systems, along with opportunities for clinical translation.

AB - The redox regulation of protein and low molecular weight (LMW) thiols has emerged as an exciting field for discovery in biomedical research and clinical implementation. Decades of basic research of redox-regulated and redox-regulatory proteins complemented by new methodologies for characterization and functional analysis of these proteins in multicellular systems have been instrumental in advancing redox concepts in medicine. Herein we describe the basics of protein and LMW thiol redox chemistry, methods of analysis and computational integration in complex systems, along with opportunities for clinical translation.

UR - https://dx.doi.org/10.1016/B978-0-323-90219-9.00006-6

M3 - Chapter

BT - Unknown book

PB - Elsevier

ER -

A thiol chemistry perspective on redox medicine

Abstract

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