Anti-inflammatory property of the urinary metabolites of nobiletin in mouse

Shiming Li; Shengmin Sang; Min Hsiung Pan; Ching Shu Lai; Chih Yu Lo; Chung S. Yang; Chi Tang Ho

doi:10.1016/j.bmcl.2007.06.096

Anti-inflammatory property of the urinary metabolites of nobiletin in mouse

Shiming Li, Shengmin Sang, Min Hsiung Pan, Ching Shu Lai, Chih Yu Lo, Chung S. Yang, Chi Tang Ho

Research output: Contribution to journal › Article › peer-review

Abstract

Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3′- and 4′-demethylnobiletin) and di-demethylation (3′,4′-didemethylnobiletin) metabolic pathway. Biological screening of nobiletin and its metabolites has revealed that the metabolites possess more potent anti-inflammatory activity than their parent compound. Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage.

Original language	English
Pages (from-to)	5177-5181
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2007.06.096
State	Published - Sep 15 2007
Externally published	Yes

Keywords

3′,4′-Didemethylnobiletin
Anti-inflammatory activity
Demethylnobiletin
Nobiletin
Nobiletin metabolites

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10.1016/j.bmcl.2007.06.096

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title = "Anti-inflammatory property of the urinary metabolites of nobiletin in mouse",

abstract = "Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3′- and 4′-demethylnobiletin) and di-demethylation (3′,4′-didemethylnobiletin) metabolic pathway. Biological screening of nobiletin and its metabolites has revealed that the metabolites possess more potent anti-inflammatory activity than their parent compound. Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage.",

keywords = "3′,4′-Didemethylnobiletin, Anti-inflammatory activity, Demethylnobiletin, Nobiletin, Nobiletin metabolites",

author = "Shiming Li and Shengmin Sang and Pan, \{Min Hsiung\} and Lai, \{Ching Shu\} and Lo, \{Chih Yu\} and Yang, \{Chung S.\} and Ho, \{Chi Tang\}",

year = "2007",

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doi = "10.1016/j.bmcl.2007.06.096",

language = "English",

volume = "17",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Anti-inflammatory property of the urinary metabolites of nobiletin in mouse

AU - Li, Shiming

AU - Sang, Shengmin

AU - Pan, Min Hsiung

AU - Lai, Ching Shu

AU - Lo, Chih Yu

AU - Yang, Chung S.

AU - Ho, Chi Tang

PY - 2007/9/15

Y1 - 2007/9/15

N2 - Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3′- and 4′-demethylnobiletin) and di-demethylation (3′,4′-didemethylnobiletin) metabolic pathway. Biological screening of nobiletin and its metabolites has revealed that the metabolites possess more potent anti-inflammatory activity than their parent compound. Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage.

AB - Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3′- and 4′-demethylnobiletin) and di-demethylation (3′,4′-didemethylnobiletin) metabolic pathway. Biological screening of nobiletin and its metabolites has revealed that the metabolites possess more potent anti-inflammatory activity than their parent compound. Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage.

KW - 3′,4′-Didemethylnobiletin

KW - Anti-inflammatory activity

KW - Demethylnobiletin

KW - Nobiletin

KW - Nobiletin metabolites

UR - https://www.scopus.com/pages/publications/34547866464

U2 - 10.1016/j.bmcl.2007.06.096

DO - 10.1016/j.bmcl.2007.06.096

M3 - Article

SN - 0960-894X

VL - 17

SP - 5177

EP - 5181

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

Anti-inflammatory property of the urinary metabolites of nobiletin in mouse

Abstract

Keywords

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