TY - JOUR
T1 - Anti-inflammatory property of the urinary metabolites of nobiletin in mouse
AU - Li, Shiming
AU - Sang, Shengmin
AU - Pan, Min-Hsiung
AU - Lai, Ching-Shu
AU - Lo, Chih-Yu
AU - Yang, Chung S.
AU - Ho, Chi-Tang
PY - 2007/9/15
Y1 - 2007/9/15
N2 - Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3′- and 4′-demethylnobiletin) and di-demethylation (3′,4′-didemethylnobiletin) metabolic pathway. Biological screening of nobiletin and its metabolites has revealed that the metabolites possess more potent anti-inflammatory activity than their parent compound. Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage. © 2007 Elsevier Ltd. All rights reserved.
AB - Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3′- and 4′-demethylnobiletin) and di-demethylation (3′,4′-didemethylnobiletin) metabolic pathway. Biological screening of nobiletin and its metabolites has revealed that the metabolites possess more potent anti-inflammatory activity than their parent compound. Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage. © 2007 Elsevier Ltd. All rights reserved.
KW - 3′,4′-Didemethylnobiletin
KW - Anti-inflammatory activity
KW - Demethylnobiletin
KW - Nobiletin
KW - Nobiletin metabolites
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U2 - 10.1016/j.bmcl.2007.06.096
DO - 10.1016/j.bmcl.2007.06.096
M3 - Article
C2 - 17644380
SN - 0960-894X
VL - 17
SP - 5177
EP - 5181
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 18
ER -