TY - JOUR
T1 - Antitumor properties of phenothiazines
AU - Motohashi, Noboru
AU - Gollapudi, Sitaraghav R.
AU - Emrani, Jahangir
AU - Bhattiprolu, Kesava R.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - The purpose of this review is to describe and evaluate the antineoplastic properties of phenothiazines. The present research studies suggest that many phenothiazines do not show significant antitumor and antineoplastic activity and so they cannot be used as potential drugs to treat cancer. However some of their derivatives help indirectly in decreasing cytotoxic effects caused by radiation and other chemical carcinogens. Additionally, some phenothiazine derivatives provide protection against cancers caused by metabolic activation of carcinogens such as dimethylbenzanthracene. The selective accumulation of phenothiazine derivatives in certain tissues such as brain and melanoma tumors may provide an effective treatment of such tumors. Current studies suggest that highly potent phenothiazine derivatives can be made by nitro substitution on the aromatic ring of phenothiazines. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
AB - The purpose of this review is to describe and evaluate the antineoplastic properties of phenothiazines. The present research studies suggest that many phenothiazines do not show significant antitumor and antineoplastic activity and so they cannot be used as potential drugs to treat cancer. However some of their derivatives help indirectly in decreasing cytotoxic effects caused by radiation and other chemical carcinogens. Additionally, some phenothiazine derivatives provide protection against cancers caused by metabolic activation of carcinogens such as dimethylbenzanthracene. The selective accumulation of phenothiazine derivatives in certain tissues such as brain and melanoma tumors may provide an effective treatment of such tumors. Current studies suggest that highly potent phenothiazine derivatives can be made by nitro substitution on the aromatic ring of phenothiazines. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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U2 - 10.3109/07357909109021328
DO - 10.3109/07357909109021328
M3 - Article
C2 - 1913233
SN - 0735-7907
VL - 9
SP - 305
EP - 319
JO - Cancer Investigation
JF - Cancer Investigation
IS - 3
ER -
