Aqueous solution properties of amphiphilic triblock copolymer poly(p-dioxanone-co-L-lactide)-block-poly(ethylene glycol)

Narayan Bhattarai; Shanta Raj Bhattarai; Myung Seob Khil; Douk Rae Lee; Hak Yong Kim

doi:10.1016/S0014-3057(03)00057-0

Aqueous solution properties of amphiphilic triblock copolymer poly(p-dioxanone-co-L-lactide)-block-poly(ethylene glycol)

Narayan Bhattarai, Shanta Raj Bhattarai, Myung Seob Khil, Douk Rae Lee, Hak Yong Kim

Chonbuk National University

Research output: Contribution to journal › Article › peer-review

Abstract

A poly(ethylene glycol) (PEG)-based new amphiphilic block copolymer bearing the poly(p-dioxanone-co-L-lactide) (PPDO/PLLA) hydrophobic moieties was prepared. Depending on the copolymer composition and molecular weights, solubility of the polymeric samples in water was varied. Its diluted aqueous solution properties were studied by viscometry, dye solubilization, ¹H-NMR and dynamic light scattering. 1,6-Diphenyl-1,3,5-hexatriene solubilization and ¹H-NMR spectra carried out in CDCl₃ and D₂O were used to prove the existence of hydrophobic domains as the core of micelle. Average particle size of 60-165 nm with low polydispersity and lower negative zeta (ξ) potential of -3 to -14 mV were observed on the aqueous copolymer dispersion.

Original language	English
Pages (from-to)	1603-1608
Number of pages	6
Journal	European Polymer Journal
Volume	39
Issue number	8
DOIs	https://doi.org/10.1016/S0014-3057(03)00057-0
State	Published - Aug 2003
Externally published	Yes

Keywords

Amphiphilic copolymer
Micelle
Poly(p-dioxanone-co-L-lactide)-block-poly(ethylene glycol)
Self-aggregation

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10.1016/S0014-3057(03)00057-0

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title = "Aqueous solution properties of amphiphilic triblock copolymer poly(p-dioxanone-co-L-lactide)-block-poly(ethylene glycol)",

abstract = "A poly(ethylene glycol) (PEG)-based new amphiphilic block copolymer bearing the poly(p-dioxanone-co-L-lactide) (PPDO/PLLA) hydrophobic moieties was prepared. Depending on the copolymer composition and molecular weights, solubility of the polymeric samples in water was varied. Its diluted aqueous solution properties were studied by viscometry, dye solubilization, 1H-NMR and dynamic light scattering. 1,6-Diphenyl-1,3,5-hexatriene solubilization and 1H-NMR spectra carried out in CDCl3 and D2O were used to prove the existence of hydrophobic domains as the core of micelle. Average particle size of 60-165 nm with low polydispersity and lower negative zeta (ξ) potential of -3 to -14 mV were observed on the aqueous copolymer dispersion.",

keywords = "Amphiphilic copolymer, Micelle, Poly(p-dioxanone-co-L-lactide)-block-poly(ethylene glycol), Self-aggregation",

author = "Narayan Bhattarai and Bhattarai, \{Shanta Raj\} and Khil, \{Myung Seob\} and Lee, \{Douk Rae\} and Kim, \{Hak Yong\}",

year = "2003",

month = aug,

doi = "10.1016/S0014-3057(03)00057-0",

language = "English",

volume = "39",

pages = "1603--1608",

journal = "European Polymer Journal",

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T1 - Aqueous solution properties of amphiphilic triblock copolymer poly(p-dioxanone-co-L-lactide)-block-poly(ethylene glycol)

AU - Bhattarai, Narayan

AU - Bhattarai, Shanta Raj

AU - Khil, Myung Seob

AU - Lee, Douk Rae

AU - Kim, Hak Yong

PY - 2003/8

Y1 - 2003/8

N2 - A poly(ethylene glycol) (PEG)-based new amphiphilic block copolymer bearing the poly(p-dioxanone-co-L-lactide) (PPDO/PLLA) hydrophobic moieties was prepared. Depending on the copolymer composition and molecular weights, solubility of the polymeric samples in water was varied. Its diluted aqueous solution properties were studied by viscometry, dye solubilization, 1H-NMR and dynamic light scattering. 1,6-Diphenyl-1,3,5-hexatriene solubilization and 1H-NMR spectra carried out in CDCl3 and D2O were used to prove the existence of hydrophobic domains as the core of micelle. Average particle size of 60-165 nm with low polydispersity and lower negative zeta (ξ) potential of -3 to -14 mV were observed on the aqueous copolymer dispersion.

AB - A poly(ethylene glycol) (PEG)-based new amphiphilic block copolymer bearing the poly(p-dioxanone-co-L-lactide) (PPDO/PLLA) hydrophobic moieties was prepared. Depending on the copolymer composition and molecular weights, solubility of the polymeric samples in water was varied. Its diluted aqueous solution properties were studied by viscometry, dye solubilization, 1H-NMR and dynamic light scattering. 1,6-Diphenyl-1,3,5-hexatriene solubilization and 1H-NMR spectra carried out in CDCl3 and D2O were used to prove the existence of hydrophobic domains as the core of micelle. Average particle size of 60-165 nm with low polydispersity and lower negative zeta (ξ) potential of -3 to -14 mV were observed on the aqueous copolymer dispersion.

KW - Amphiphilic copolymer

KW - Micelle

KW - Poly(p-dioxanone-co-L-lactide)-block-poly(ethylene glycol)

KW - Self-aggregation

UR - https://www.scopus.com/pages/publications/0037810805

U2 - 10.1016/S0014-3057(03)00057-0

DO - 10.1016/S0014-3057(03)00057-0

M3 - Article

SN - 0014-3057

VL - 39

SP - 1603

EP - 1608

JO - European Polymer Journal

JF - European Polymer Journal

IS - 8

ER -

Aqueous solution properties of amphiphilic triblock copolymer poly(p-dioxanone-co-L-lactide)-block-poly(ethylene glycol)

Abstract

Keywords

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