Bioassay-guided isolation, identification, and quantification of the estrogen-like constituent from PC SPES

Shengmin Sang; Zhihua Liu; Robert T. Rosen; Chi-Tang Ho

Bioassay-guided isolation, identification, and quantification of the estrogen-like constituent from PC SPES

Shengmin Sang
, Zhihua Liu
, Robert T. Rosen
, Chi-Tang Ho

Family and Consumer Sciences

Ernest Mario School of Pharmacy
Rutgers, Stt. Univ. of New Jersey

Research output: Contribution to journal › Conference article › peer-review

2 Scopus citations

Abstract

The herbal mixture PC SPES, a dietary supplement for patients with prostate cancer, has been proved to have estrogenic activity in clinical trials. To determine the active components in PC SPES for estrogenic activity, a bioassay-guided fractionation of PC SPES using a functional estrogen receptor (ER) assay led to the isolation and identification of the most active constituent, ethinyl estradiol, together with two flavonones, neobaicalein and tenaxin I. The isolation, identification and quantification of ethinyl estradiol are discussed. © 2006 American Chemical Society.

Original language	English
Pages (from-to)	117-125
Number of pages	9
Journal	ACS Symposium Series
Volume	925
State	Published - Dec 1 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "Bioassay-guided isolation, identification, and quantification of the estrogen-like constituent from PC SPES",

abstract = "The herbal mixture PC SPES, a dietary supplement for patients with prostate cancer, has been proved to have estrogenic activity in clinical trials. To determine the active components in PC SPES for estrogenic activity, a bioassay-guided fractionation of PC SPES using a functional estrogen receptor (ER) assay led to the isolation and identification of the most active constituent, ethinyl estradiol, together with two flavonones, neobaicalein and tenaxin I. The isolation, identification and quantification of ethinyl estradiol are discussed. {\textcopyright} 2006 American Chemical Society.",

author = "Shengmin Sang and Zhihua Liu and Rosen, \{Robert T.\} and Chi-Tang Ho",

year = "2006",

month = dec,

day = "1",

language = "English",

volume = "925",

pages = "117--125",

journal = "ACS Symposium Series",

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T1 - Bioassay-guided isolation, identification, and quantification of the estrogen-like constituent from PC SPES

AU - Sang, Shengmin

AU - Liu, Zhihua

AU - Rosen, Robert T.

AU - Ho, Chi-Tang

PY - 2006/12/1

Y1 - 2006/12/1

N2 - The herbal mixture PC SPES, a dietary supplement for patients with prostate cancer, has been proved to have estrogenic activity in clinical trials. To determine the active components in PC SPES for estrogenic activity, a bioassay-guided fractionation of PC SPES using a functional estrogen receptor (ER) assay led to the isolation and identification of the most active constituent, ethinyl estradiol, together with two flavonones, neobaicalein and tenaxin I. The isolation, identification and quantification of ethinyl estradiol are discussed. © 2006 American Chemical Society.

AB - The herbal mixture PC SPES, a dietary supplement for patients with prostate cancer, has been proved to have estrogenic activity in clinical trials. To determine the active components in PC SPES for estrogenic activity, a bioassay-guided fractionation of PC SPES using a functional estrogen receptor (ER) assay led to the isolation and identification of the most active constituent, ethinyl estradiol, together with two flavonones, neobaicalein and tenaxin I. The isolation, identification and quantification of ethinyl estradiol are discussed. © 2006 American Chemical Society.

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M3 - Conference article

SN - 0097-6156

VL - 925

SP - 117

EP - 125

JO - ACS Symposium Series

JF - ACS Symposium Series

ER -

Bioassay-guided isolation, identification, and quantification of the estrogen-like constituent from PC SPES

Abstract

UN SDGs

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