TY - JOUR
T1 - Bioassay-guided isolation, identification, and quantification of the estrogen-like constituent from PC SPES
AU - Sang, Shengmin
AU - Liu, Zhihua
AU - Rosen, Robert T.
AU - Ho, Chi-Tang
PY - 2006/12/1
Y1 - 2006/12/1
N2 - The herbal mixture PC SPES, a dietary supplement for patients with prostate cancer, has been proved to have estrogenic activity in clinical trials. To determine the active components in PC SPES for estrogenic activity, a bioassay-guided fractionation of PC SPES using a functional estrogen receptor (ER) assay led to the isolation and identification of the most active constituent, ethinyl estradiol, together with two flavonones, neobaicalein and tenaxin I. The isolation, identification and quantification of ethinyl estradiol are discussed. © 2006 American Chemical Society.
AB - The herbal mixture PC SPES, a dietary supplement for patients with prostate cancer, has been proved to have estrogenic activity in clinical trials. To determine the active components in PC SPES for estrogenic activity, a bioassay-guided fractionation of PC SPES using a functional estrogen receptor (ER) assay led to the isolation and identification of the most active constituent, ethinyl estradiol, together with two flavonones, neobaicalein and tenaxin I. The isolation, identification and quantification of ethinyl estradiol are discussed. © 2006 American Chemical Society.
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M3 - Conference article
SN - 0097-6156
VL - 925
SP - 117
EP - 125
JO - ACS Symposium Series
JF - ACS Symposium Series
ER -
