Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation

Shanta R Bhattarai; Santosh Aryal; Remant Bahadur K.C.; Narayan Bhattarai; Pyong Han Hwang; Ho Keun Yi; Hak Yong Kim

doi:10.1016/j.msec.2006.11.008

Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation

Shanta R Bhattarai
, Santosh Aryal
, Remant Bahadur K.C.
, Narayan Bhattarai
, Pyong Han Hwang
, Ho Keun Yi
, Hak Yong Kim

Chemical, Biological, and Bio Engineering

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

This communication reports that a plasmid DNA molecule could spontaneously interact with hydroxyapatite (HA) functionalized multi-walled carbon nanotubes (MWNTs-HA) in water-solute environment. Gel electrophoresis, UV absorption, FT-IR, and Raman spectra were used to characterize MWNTs-HA/DNA complexes. AFM and TEM images revealed that DNA induces the de-aggregation of MWNTs-HA. Our preliminary study suggests that the plasmid DNA significantly interacted with MWNTs-HA, and formed the stable complex, and could find the application in nanotechnology for gene delivery system. © 2006 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	64-69
Number of pages	6
Journal	Materials Science and Engineering C
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.msec.2006.11.008
State	Published - Jan 10 2008

Keywords

Biomaterials
Calcium compounds
Carbon nanotubes
Nanomaterials, DNA

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10.1016/j.msec.2006.11.008

Cite this

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title = "Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation",

abstract = "This communication reports that a plasmid DNA molecule could spontaneously interact with hydroxyapatite (HA) functionalized multi-walled carbon nanotubes (MWNTs-HA) in water-solute environment. Gel electrophoresis, UV absorption, FT-IR, and Raman spectra were used to characterize MWNTs-HA/DNA complexes. AFM and TEM images revealed that DNA induces the de-aggregation of MWNTs-HA. Our preliminary study suggests that the plasmid DNA significantly interacted with MWNTs-HA, and formed the stable complex, and could find the application in nanotechnology for gene delivery system. {\textcopyright} 2006 Elsevier B.V. All rights reserved.",

keywords = "Biomaterials, Calcium compounds, Carbon nanotubes, Nanomaterials, DNA",

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T1 - Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation

AU - Bhattarai, Shanta R

AU - Aryal, Santosh

AU - Bahadur K.C., Remant

AU - Bhattarai, Narayan

AU - Han Hwang, Pyong

AU - Keun Yi, Ho

AU - Yong Kim, Hak

PY - 2008/1/10

Y1 - 2008/1/10

N2 - This communication reports that a plasmid DNA molecule could spontaneously interact with hydroxyapatite (HA) functionalized multi-walled carbon nanotubes (MWNTs-HA) in water-solute environment. Gel electrophoresis, UV absorption, FT-IR, and Raman spectra were used to characterize MWNTs-HA/DNA complexes. AFM and TEM images revealed that DNA induces the de-aggregation of MWNTs-HA. Our preliminary study suggests that the plasmid DNA significantly interacted with MWNTs-HA, and formed the stable complex, and could find the application in nanotechnology for gene delivery system. © 2006 Elsevier B.V. All rights reserved.

AB - This communication reports that a plasmid DNA molecule could spontaneously interact with hydroxyapatite (HA) functionalized multi-walled carbon nanotubes (MWNTs-HA) in water-solute environment. Gel electrophoresis, UV absorption, FT-IR, and Raman spectra were used to characterize MWNTs-HA/DNA complexes. AFM and TEM images revealed that DNA induces the de-aggregation of MWNTs-HA. Our preliminary study suggests that the plasmid DNA significantly interacted with MWNTs-HA, and formed the stable complex, and could find the application in nanotechnology for gene delivery system. © 2006 Elsevier B.V. All rights reserved.

KW - Biomaterials

KW - Calcium compounds

KW - Carbon nanotubes

KW - Nanomaterials, DNA

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JO - Materials Science and Engineering C

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Carbon nanotube-hydroxyapatite nanocomposite for DNA complexation

Abstract

Keywords

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