Commonly administered medicines that could impact human gut microflora

This review summarizes how certain commonly used medications could negatively impact the gut microbiota in the elderly. The elderly population is inherently more susceptible to gastrointestinal problems and diseases due to significant age-related gastrointestinal changes experienced in gut physiology, reactivity of the immune system, and/or diet. These factors, coupled with increased occurrence of disease and corresponding medication use, could also modify the composition of gut microbiota. The impact of non-steroidal anti-inflammatory drugs (NSAIDs) on the physical gastrointestinal tract has already been shown. However, the impact of these factors on the microbiota inhabiting the GI tract has not been well established. A better understanding of the relationship between medication use and gut microbiota composition may have beneficial implications for general and elderly health.