Cytotoxic lignans from Larrea tridentata

Joshua D. Lambert; Shengmin Sang; Ann Dougherty; Colby G. Caldwell; Ross O. Meyers; Robert T. Dorr; Barbara N. Timmermann

doi:10.1016/j.phytochem.2005.02.007

Cytotoxic lignans from Larrea tridentata

Joshua D. Lambert
, Shengmin Sang
, Ann Dougherty
, Colby G. Caldwell
, Ross O. Meyers
, Robert T. Dorr
, Barbara N. Timmermann

Family and Consumer Sciences

Ernest Mario School of Pharmacy
The University of Arizona
University of Arizona Cancer Center

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Six lignans, including the cyclolignan 3,4′-dihydroxy-3′, 4′-dimethoxy-6,7′-cyclolignan, were isolated from the flowering tops of Larrea tridentata. Additionally the flavanone, (S)-4′,5-dihydroxy-7- methoxyflavanone, was isolated for the first time from L. tridentata or any member of the family Zygophyllaceae. All of the compounds were assessed for their growth inhibitory activity against human breast cancer, human colon cancer and human melanoma cell lines. The lignans had IC50 values of 5-60 μM with the linear butane-type lignans being the most potent, and it was found that colon cancer cells were the least sensitive cell type tested. The relative potency of linear butane type lignans against human breast cancer appears to correlate positively with the number of O-methyl groups present on the molecule. © 2005 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	811-815
Number of pages	5
Journal	Phytochemistry
Volume	66
Issue number	7
DOIs	https://doi.org/10.1016/j.phytochem.2005.02.007
State	Published - Jan 1 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Creosote bush
Cytotoxicity
Flavanone
Larrea tridentata
Lignans
Zygophyllaceae

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10.1016/j.phytochem.2005.02.007

Cite this

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title = "Cytotoxic lignans from Larrea tridentata",

abstract = "Six lignans, including the cyclolignan 3,4′-dihydroxy-3′, 4′-dimethoxy-6,7′-cyclolignan, were isolated from the flowering tops of Larrea tridentata. Additionally the flavanone, (S)-4′,5-dihydroxy-7- methoxyflavanone, was isolated for the first time from L. tridentata or any member of the family Zygophyllaceae. All of the compounds were assessed for their growth inhibitory activity against human breast cancer, human colon cancer and human melanoma cell lines. The lignans had IC50 values of 5-60 μM with the linear butane-type lignans being the most potent, and it was found that colon cancer cells were the least sensitive cell type tested. The relative potency of linear butane type lignans against human breast cancer appears to correlate positively with the number of O-methyl groups present on the molecule. {\textcopyright} 2005 Elsevier Ltd. All rights reserved.",

keywords = "Cancer, Creosote bush, Cytotoxicity, Flavanone, Larrea tridentata, Lignans, Zygophyllaceae",

author = "Lambert, \{Joshua D.\} and Shengmin Sang and Ann Dougherty and Caldwell, \{Colby G.\} and Meyers, \{Ross O.\} and Dorr, \{Robert T.\} and Timmermann, \{Barbara N.\}",

year = "2005",

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day = "1",

doi = "10.1016/j.phytochem.2005.02.007",

language = "English",

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T1 - Cytotoxic lignans from Larrea tridentata

AU - Lambert, Joshua D.

AU - Sang, Shengmin

AU - Dougherty, Ann

AU - Caldwell, Colby G.

AU - Meyers, Ross O.

AU - Dorr, Robert T.

AU - Timmermann, Barbara N.

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Six lignans, including the cyclolignan 3,4′-dihydroxy-3′, 4′-dimethoxy-6,7′-cyclolignan, were isolated from the flowering tops of Larrea tridentata. Additionally the flavanone, (S)-4′,5-dihydroxy-7- methoxyflavanone, was isolated for the first time from L. tridentata or any member of the family Zygophyllaceae. All of the compounds were assessed for their growth inhibitory activity against human breast cancer, human colon cancer and human melanoma cell lines. The lignans had IC50 values of 5-60 μM with the linear butane-type lignans being the most potent, and it was found that colon cancer cells were the least sensitive cell type tested. The relative potency of linear butane type lignans against human breast cancer appears to correlate positively with the number of O-methyl groups present on the molecule. © 2005 Elsevier Ltd. All rights reserved.

AB - Six lignans, including the cyclolignan 3,4′-dihydroxy-3′, 4′-dimethoxy-6,7′-cyclolignan, were isolated from the flowering tops of Larrea tridentata. Additionally the flavanone, (S)-4′,5-dihydroxy-7- methoxyflavanone, was isolated for the first time from L. tridentata or any member of the family Zygophyllaceae. All of the compounds were assessed for their growth inhibitory activity against human breast cancer, human colon cancer and human melanoma cell lines. The lignans had IC50 values of 5-60 μM with the linear butane-type lignans being the most potent, and it was found that colon cancer cells were the least sensitive cell type tested. The relative potency of linear butane type lignans against human breast cancer appears to correlate positively with the number of O-methyl groups present on the molecule. © 2005 Elsevier Ltd. All rights reserved.

KW - Cancer

KW - Creosote bush

KW - Cytotoxicity

KW - Flavanone

KW - Larrea tridentata

KW - Lignans

KW - Zygophyllaceae

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U2 - 10.1016/j.phytochem.2005.02.007

DO - 10.1016/j.phytochem.2005.02.007

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C2 - 15797607

SN - 0031-9422

VL - 66

SP - 811

EP - 815

JO - Phytochemistry

JF - Phytochemistry

IS - 7

ER -

Cytotoxic lignans from Larrea tridentata

Abstract

UN SDGs

Keywords

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