Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12

Jielin Sun; Siqun Lilly Zheng; Fredrik Wiklund; Sarah D. Isaacs; Lina D. Purcell; Zhengrong Gao; Fang-Chi Hsu; Seongtae Kim; Wennuan Liu; Yi Zhu; Pär Stattin; Hans-Olov Adami; Kathleen E. Wiley; Latchezar Dimitrov; Jishan Sun; Tao Li; Aubrey R. Turner; Tamara S. Adams; Jan Adolfsson; Jan-Erik Johansson; James Lowey; Bruce J. Trock; Alan W. Partin; Patrick C. Walsh; Jeffrey M. Trent; David Duggan; John Carpten; Bao-Li Chang; Henrik Grönberg; William B. Isaacs; Jianfeng Xu

doi:10.1038/ng.214

Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12

Jielin Sun
, Siqun Lilly Zheng
, Fredrik Wiklund
, Sarah D. Isaacs
, Lina D. Purcell
, Zhengrong Gao
, Fang-Chi Hsu
, Seongtae Kim
, Wennuan Liu
, Yi Zhu
, Pär Stattin
, Hans-Olov Adami
, Kathleen E. Wiley
, Latchezar Dimitrov
, Jishan Sun
, Tao Li
, Aubrey R. Turner
, Tamara S. Adams
, Jan Adolfsson
, Jan-Erik Johansson

James Lowey, Bruce J. Trock, Alan W. Partin, Patrick C. Walsh, Jeffrey M. Trent, David Duggan, John Carpten, Bao-Li Chang, Henrik Grönberg, William B. Isaacs, Jianfeng Xu

Mathematics and Statistics

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Abstract

We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

Original language	English
Pages (from-to)	1153-1155
Number of pages	3
Journal	Nature Genetics
Volume	40
Issue number	10
DOIs	https://doi.org/10.1038/ng.214
State	Published - Oct 1 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.214

Cite this

Sun, J., Zheng, S. L., Wiklund, F., Isaacs, S. D., Purcell, L. D., Gao, Z., Hsu, F.-C., Kim, S., Liu, W., Zhu, Y., Stattin, P., Adami, H.-O., Wiley, K. E., Dimitrov, L., Sun, J., Li, T., Turner, A. R., Adams, T. S., Adolfsson, J., ... Xu, J. (2008). Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nature Genetics, 40(10), 1153-1155. https://doi.org/10.1038/ng.214

@article{555896b99ec04017aa83cf3e9ed7c4e9,

title = "Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12",

abstract = "We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.",

author = "Jielin Sun and Zheng, \{Siqun Lilly\} and Fredrik Wiklund and Isaacs, \{Sarah D.\} and Purcell, \{Lina D.\} and Zhengrong Gao and Fang-Chi Hsu and Seongtae Kim and Wennuan Liu and Yi Zhu and P{\"a}r Stattin and Hans-Olov Adami and Wiley, \{Kathleen E.\} and Latchezar Dimitrov and Jishan Sun and Tao Li and Turner, \{Aubrey R.\} and Adams, \{Tamara S.\} and Jan Adolfsson and Jan-Erik Johansson and James Lowey and Trock, \{Bruce J.\} and Partin, \{Alan W.\} and Walsh, \{Patrick C.\} and Trent, \{Jeffrey M.\} and David Duggan and John Carpten and Bao-Li Chang and Henrik Gr{\"o}nberg and Isaacs, \{William B.\} and Jianfeng Xu",

year = "2008",

month = oct,

day = "1",

doi = "10.1038/ng.214",

language = "English",

volume = "40",

pages = "1153--1155",

journal = "Nature Genetics",

issn = "1061-4036",

number = "10",

}

Sun, J, Zheng, SL, Wiklund, F, Isaacs, SD, Purcell, LD, Gao, Z, Hsu, F-C, Kim, S, Liu, W, Zhu, Y, Stattin, P, Adami, H-O, Wiley, KE, Dimitrov, L, Sun, J, Li, T, Turner, AR, Adams, TS, Adolfsson, J, Johansson, J-E, Lowey, J, Trock, BJ, Partin, AW, Walsh, PC, Trent, JM, Duggan, D, Carpten, J, Chang, B-L, Grönberg, H, Isaacs, WB & Xu, J 2008, 'Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12', Nature Genetics, vol. 40, no. 10, pp. 1153-1155. https://doi.org/10.1038/ng.214

TY - JOUR

T1 - Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12

AU - Sun, Jielin

AU - Zheng, Siqun Lilly

AU - Wiklund, Fredrik

AU - Isaacs, Sarah D.

AU - Purcell, Lina D.

AU - Gao, Zhengrong

AU - Hsu, Fang-Chi

AU - Kim, Seongtae

AU - Liu, Wennuan

AU - Zhu, Yi

AU - Stattin, Pär

AU - Adami, Hans-Olov

AU - Wiley, Kathleen E.

AU - Dimitrov, Latchezar

AU - Sun, Jishan

AU - Li, Tao

AU - Turner, Aubrey R.

AU - Adams, Tamara S.

AU - Adolfsson, Jan

AU - Johansson, Jan-Erik

AU - Lowey, James

AU - Trock, Bruce J.

AU - Partin, Alan W.

AU - Walsh, Patrick C.

AU - Trent, Jeffrey M.

AU - Duggan, David

AU - Carpten, John

AU - Chang, Bao-Li

AU - Grönberg, Henrik

AU - Isaacs, William B.

AU - Xu, Jianfeng

PY - 2008/10/1

Y1 - 2008/10/1

N2 - We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

AB - We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, ∼26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10-9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=52949115663&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=52949115663&origin=inward

U2 - 10.1038/ng.214

DO - 10.1038/ng.214

M3 - Article

C2 - 18758462

SN - 1061-4036

VL - 40

SP - 1153

EP - 1155

JO - Nature Genetics

JF - Nature Genetics

IS - 10

ER -

Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this