Flurbiprofen axetil loaded coaxial electrospun poly(vinyl pyrrolidone)-nanopoly(lactic-co-glycolic acid) core-shell composite nanofibers: Preparation, characterization, and anti-adhesion activity

Flurbiprofen axetil (FA)-loaded coaxial electrospun poly(vinyl pyrrolidone) (PVP)-nanopoly(lactic-co-glycolic acid) core-shell composite nanofibers were successfully fabricated by a facile coaxial electrospinning, and an electrospun drug-loaded system was formed for anti-adhesion applications. The FA, which is a kind of lipid microsphere nonsteroidal anti-inflammatory drug, was shown to be successfully adsorbed in the PVP, and the formed poly(lactic-co-glycolic acid) (PLGA)/PVP/FA composite nanofibers exhibited a uniform and smooth morphology. The cell viability assay and cell morphology observation revealed that the formed PLGA/PVP/FA composite nanofibers were cytocompatible. Importantly, the loaded FA within the PLGA/PVP coaxial nanofibers showed a sustained-release profile and anti-adhesion activity to inhibit the growth of the IEC-6 and NIH3T3 model cells. With the significantly reduced burst-release profile, good cytocompatibility, and anti-adhesion activity, the developed PLGA/PVP/FA composite nanofibers were proposed to be a promising material in the fields of tissue engineering and pharmaceutical science.