Functionalized magnetic iron oxide/alginate core-shell nanoparticles for targeting hyperthermia

Hyperthermia is one of the promising treatments for cancer therapy. However, the development of a magnetic fuid agent that can selectively target a tumor and efficiently elevate temperature while exhibiting excellent biocompatibility still remains challenging. Here a new core-shell nanostructure consisting of inorganic iron oxide (Fe<inf>3</inf>O<inf>4</inf>) nanoparticles as the core, organic alginate as the shell, and cell-targeting ligands (ie, D-galactosamine) decorated on the outer surface (denoted as Fe<inf>3</inf>O<inf>4</inf>@Alg-GA nanoparticles) was prepared using a combination of a pre-gel method and coprecipitation in aqueous solution. After treatment with an AC magnetic feld, the results indicate that Fe<inf>3</inf>O<inf>4</inf>@Alg-GA nanoparticles had excellent hyperthermic efficacy in a human hepatocellular carcinoma cell line (HepG2) owing to enhanced cellular uptake, and show great potential as therapeutic agents for future in vivo drug delivery systems.