Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells

Min Hsiung Pan; Hui Jun Kang; Wei Jen Chen; Chih Yu Lo; Shiming Li; Shengmin Sang; Chi Tang Ho

doi:10.1021/bk-2008-0993.ch029

Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells

Min Hsiung Pan, Hui Jun Kang, Wei Jen Chen, Chih Yu Lo, Shiming Li, Shengmin Sang, Chi Tang Ho

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The growth inhibitory effects of black tea polyphenol, theaflavin (TF-1) and its peracetylated derivative (ATF-1) in human leukemia cancer cells were examined. TF-1 and ATF-1 displayed strong growth inhibitory effects against human leukemia HL-60 cells. ATF-1 was more potent against the growth of HL-60 cells and induction of apoptosis through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). ROS generation occurs in the early stages of ATF-1-induced apoptosis, preceding cytochrome c release, caspase activation, and DNA fragmentation. The molecular mechanism of ATF-1-induced apoptosis was also investigated.

Original language	English
Title of host publication	Functional Food and Health
Publisher	American Chemical Society
Pages	345-361
Number of pages	17
ISBN (Print)	9780841269828
DOIs	https://doi.org/10.1021/bk-2008-0993.ch029
State	Published - Sep 19 2008
Externally published	Yes

Publication series

Name	ACS Symposium Series
Volume	993
ISSN (Print)	0097-6156
ISSN (Electronic)	1947-5918

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10.1021/bk-2008-0993.ch029

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Pan, M. H., Kang, H. J., Chen, W. J., Lo, C. Y., Li, S., Sang, S., & Ho, C. T. (2008). Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells. In Functional Food and Health (pp. 345-361). (ACS Symposium Series; Vol. 993). American Chemical Society. https://doi.org/10.1021/bk-2008-0993.ch029

@inproceedings{0ec6f8a4f0474053a197a8b0390c498f,

title = "Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells",

abstract = "The growth inhibitory effects of black tea polyphenol, theaflavin (TF-1) and its peracetylated derivative (ATF-1) in human leukemia cancer cells were examined. TF-1 and ATF-1 displayed strong growth inhibitory effects against human leukemia HL-60 cells. ATF-1 was more potent against the growth of HL-60 cells and induction of apoptosis through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). ROS generation occurs in the early stages of ATF-1-induced apoptosis, preceding cytochrome c release, caspase activation, and DNA fragmentation. The molecular mechanism of ATF-1-induced apoptosis was also investigated.",

author = "Pan, \{Min Hsiung\} and Kang, \{Hui Jun\} and Chen, \{Wei Jen\} and Lo, \{Chih Yu\} and Shiming Li and Shengmin Sang and Ho, \{Chi Tang\}",

year = "2008",

month = sep,

day = "19",

doi = "10.1021/bk-2008-0993.ch029",

language = "English",

isbn = "9780841269828",

series = "ACS Symposium Series",

publisher = "American Chemical Society",

pages = "345--361",

booktitle = "Functional Food and Health",

}

Pan, MH, Kang, HJ, Chen, WJ, Lo, CY, Li, S, Sang, S & Ho, CT 2008, Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells. in Functional Food and Health. ACS Symposium Series, vol. 993, American Chemical Society, pp. 345-361. https://doi.org/10.1021/bk-2008-0993.ch029

Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells. / Pan, Min Hsiung; Kang, Hui Jun; Chen, Wei Jen et al.
Functional Food and Health. American Chemical Society, 2008. p. 345-361 (ACS Symposium Series; Vol. 993).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells

AU - Pan, Min Hsiung

AU - Kang, Hui Jun

AU - Chen, Wei Jen

AU - Lo, Chih Yu

AU - Li, Shiming

AU - Sang, Shengmin

AU - Ho, Chi Tang

PY - 2008/9/19

Y1 - 2008/9/19

N2 - The growth inhibitory effects of black tea polyphenol, theaflavin (TF-1) and its peracetylated derivative (ATF-1) in human leukemia cancer cells were examined. TF-1 and ATF-1 displayed strong growth inhibitory effects against human leukemia HL-60 cells. ATF-1 was more potent against the growth of HL-60 cells and induction of apoptosis through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). ROS generation occurs in the early stages of ATF-1-induced apoptosis, preceding cytochrome c release, caspase activation, and DNA fragmentation. The molecular mechanism of ATF-1-induced apoptosis was also investigated.

AB - The growth inhibitory effects of black tea polyphenol, theaflavin (TF-1) and its peracetylated derivative (ATF-1) in human leukemia cancer cells were examined. TF-1 and ATF-1 displayed strong growth inhibitory effects against human leukemia HL-60 cells. ATF-1 was more potent against the growth of HL-60 cells and induction of apoptosis through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). ROS generation occurs in the early stages of ATF-1-induced apoptosis, preceding cytochrome c release, caspase activation, and DNA fragmentation. The molecular mechanism of ATF-1-induced apoptosis was also investigated.

UR - https://www.scopus.com/pages/publications/84905578991

U2 - 10.1021/bk-2008-0993.ch029

DO - 10.1021/bk-2008-0993.ch029

M3 - Conference contribution

AN - SCOPUS:84905578991

SN - 9780841269828

T3 - ACS Symposium Series

SP - 345

EP - 361

BT - Functional Food and Health

PB - American Chemical Society

ER -

Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells

Abstract

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