Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells

Min-Hsiung Pan; Hui-Jun Kang; Wei-Jen Chen; Chih-Yu Lo; Shiming Li; Shengmin Sang; Chi-Tang Ho

doi:10.1021/bk-2008-0993.ch029

Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells

Min-Hsiung Pan
, Hui-Jun Kang
, Wei-Jen Chen
, Chih-Yu Lo
, Shiming Li
, Shengmin Sang
, Chi-Tang Ho

Family and Consumer Sciences

National Kaohsiung Marine University
Chung Shan Medical University
Rutgers, Stt. Univ. of New Jersey
Ernest Mario School of Pharmacy

Research output: Contribution to journal › Conference article › peer-review

Abstract

The growth inhibitory effects of black tea polyphenol, theaflavin (TF-1) and its peracetylated derivative (ATF-1) in human leukemia cancer cells were examined. TF-1 and ATF-1 displayed strong growth inhibitory effects against human leukemia HL-60 cells. ATF-1 was more potent against the growth of HL-60 cells and induction of apoptosis through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). ROS generation occurs in the early stages of ATF-1-induced apoptosis, preceding cytochrome c release, caspase activation, and DNA fragmentation. The molecular mechanism of ATF-1-induced apoptosis was also investigated. © 2008 American Chemical Society.

Original language	English
Pages (from-to)	345-361
Number of pages	17
Journal	ACS Symposium Series
Volume	993
DOIs	https://doi.org/10.1021/bk-2008-0993.ch029
State	Published - Sep 19 2008

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SDG 3 Good Health and Well-being

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10.1021/bk-2008-0993.ch029

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@article{9ed8048df1624366abcb7d81d5556362,

title = "Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells",

abstract = "The growth inhibitory effects of black tea polyphenol, theaflavin (TF-1) and its peracetylated derivative (ATF-1) in human leukemia cancer cells were examined. TF-1 and ATF-1 displayed strong growth inhibitory effects against human leukemia HL-60 cells. ATF-1 was more potent against the growth of HL-60 cells and induction of apoptosis through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). ROS generation occurs in the early stages of ATF-1-induced apoptosis, preceding cytochrome c release, caspase activation, and DNA fragmentation. The molecular mechanism of ATF-1-induced apoptosis was also investigated. {\textcopyright} 2008 American Chemical Society.",

author = "Min-Hsiung Pan and Hui-Jun Kang and Wei-Jen Chen and Chih-Yu Lo and Shiming Li and Shengmin Sang and Chi-Tang Ho",

year = "2008",

month = sep,

day = "19",

doi = "10.1021/bk-2008-0993.ch029",

language = "English",

volume = "993",

pages = "345--361",

journal = "ACS Symposium Series",

issn = "0097-6156",

publisher = "American Chemical [email protected]",

}

Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells. / Pan, Min-Hsiung; Kang, Hui-Jun; Chen, Wei-Jen et al.
In: ACS Symposium Series, Vol. 993, 19.09.2008, p. 345-361.

Research output: Contribution to journal › Conference article › peer-review

TY - JOUR

T1 - Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells

AU - Pan, Min-Hsiung

AU - Kang, Hui-Jun

AU - Chen, Wei-Jen

AU - Lo, Chih-Yu

AU - Li, Shiming

AU - Sang, Shengmin

AU - Ho, Chi-Tang

PY - 2008/9/19

Y1 - 2008/9/19

N2 - The growth inhibitory effects of black tea polyphenol, theaflavin (TF-1) and its peracetylated derivative (ATF-1) in human leukemia cancer cells were examined. TF-1 and ATF-1 displayed strong growth inhibitory effects against human leukemia HL-60 cells. ATF-1 was more potent against the growth of HL-60 cells and induction of apoptosis through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). ROS generation occurs in the early stages of ATF-1-induced apoptosis, preceding cytochrome c release, caspase activation, and DNA fragmentation. The molecular mechanism of ATF-1-induced apoptosis was also investigated. © 2008 American Chemical Society.

AB - The growth inhibitory effects of black tea polyphenol, theaflavin (TF-1) and its peracetylated derivative (ATF-1) in human leukemia cancer cells were examined. TF-1 and ATF-1 displayed strong growth inhibitory effects against human leukemia HL-60 cells. ATF-1 was more potent against the growth of HL-60 cells and induction of apoptosis through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). ROS generation occurs in the early stages of ATF-1-induced apoptosis, preceding cytochrome c release, caspase activation, and DNA fragmentation. The molecular mechanism of ATF-1-induced apoptosis was also investigated. © 2008 American Chemical Society.

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U2 - 10.1021/bk-2008-0993.ch029

DO - 10.1021/bk-2008-0993.ch029

M3 - Conference article

SN - 0097-6156

VL - 993

SP - 345

EP - 361

JO - ACS Symposium Series

JF - ACS Symposium Series

ER -

Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia HL-60 cells

Abstract

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