Inorganic-organic hybrid nanoparticles with biocompatible calcium phosphate thin shells for fluorescence enhancement

Bishnu Prasad Bastakoti; Yin-Chu Hsu; Shih-Hsiang Liao; Kevin C.-W. Wu; Masamichi Inoue; Shin-Ichi Yusa; Kenichi Nakashima; Yusuke Yamauchi

doi:10.1002/asia.201300072

Inorganic-organic hybrid nanoparticles with biocompatible calcium phosphate thin shells for fluorescence enhancement

Bishnu Prasad Bastakoti
, Yin-Chu Hsu
, Shih-Hsiang Liao
, Kevin C.-W. Wu
, Masamichi Inoue
, Shin-Ichi Yusa
, Kenichi Nakashima
, Yusuke Yamauchi

Chemistry

National Institute for Materials Science
National Taiwan University
University of Hyogo
Saga University
Japan Science and Technology Agency
Waseda University

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Polymeric micelles consisting of asymmetric triblock copolymers were successfully used for fabrication of robust hybrid nanoparticles with highly biocompatible calcium phosphate shells. The hydrophobic polystyrene core encapsulates hydrophobic fluorescent dyes such as Nile red. The anionic polyacrylic acid provides the site for the mineralization reaction of calcium phosphate. The polyethylene glycol corona stabilizes the hybrid nanoparticles. Fluorescent dyes can be used as imaging agents for determining the location of the nanoparticles and to give an observable indication of drug delivery, while the calcium phosphate shell can enhance the fluorescence of the encapsulated dye. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	1301-1305
Number of pages	5
Journal	Chemistry - An Asian Journal
Volume	8
Issue number	6
DOIs	https://doi.org/10.1002/asia.201300072
State	Published - Jun 1 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

calcium phosphate
cancer
drug delivery
fluorescent probes
micelles

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10.1002/asia.201300072

Cite this

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title = "Inorganic-organic hybrid nanoparticles with biocompatible calcium phosphate thin shells for fluorescence enhancement",

abstract = "Polymeric micelles consisting of asymmetric triblock copolymers were successfully used for fabrication of robust hybrid nanoparticles with highly biocompatible calcium phosphate shells. The hydrophobic polystyrene core encapsulates hydrophobic fluorescent dyes such as Nile red. The anionic polyacrylic acid provides the site for the mineralization reaction of calcium phosphate. The polyethylene glycol corona stabilizes the hybrid nanoparticles. Fluorescent dyes can be used as imaging agents for determining the location of the nanoparticles and to give an observable indication of drug delivery, while the calcium phosphate shell can enhance the fluorescence of the encapsulated dye. Copyright {\textcopyright} 2013 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

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AU - Bastakoti, Bishnu Prasad

AU - Hsu, Yin-Chu

AU - Liao, Shih-Hsiang

AU - Wu, Kevin C.-W.

AU - Inoue, Masamichi

AU - Yusa, Shin-Ichi

AU - Nakashima, Kenichi

AU - Yamauchi, Yusuke

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AB - Polymeric micelles consisting of asymmetric triblock copolymers were successfully used for fabrication of robust hybrid nanoparticles with highly biocompatible calcium phosphate shells. The hydrophobic polystyrene core encapsulates hydrophobic fluorescent dyes such as Nile red. The anionic polyacrylic acid provides the site for the mineralization reaction of calcium phosphate. The polyethylene glycol corona stabilizes the hybrid nanoparticles. Fluorescent dyes can be used as imaging agents for determining the location of the nanoparticles and to give an observable indication of drug delivery, while the calcium phosphate shell can enhance the fluorescence of the encapsulated dye. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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KW - cancer

KW - drug delivery

KW - fluorescent probes

KW - micelles

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Inorganic-organic hybrid nanoparticles with biocompatible calcium phosphate thin shells for fluorescence enhancement

Abstract

UN SDGs

Keywords

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