TY - JOUR
T1 - Integrating intramuscular fat radiomics with hamstrings-to-quadriceps structure and function ratios to predict future hamstring strain injury
AU - Sharma, Akanksha
AU - Smith, Daniel R
AU - Slutsky-Ganesh, Alexis B
AU - Diekfuss, Jed A
AU - Hogg, Jennifer A
AU - Foss, Kim D Barber
AU - Riehm, Christopher D
AU - Ogier, Augustin C
AU - Michel, Constance P
AU - Bendahan, David
AU - Danilkowicz, Richard
AU - Lamplot, Joseph
AU - Hill, Destin
AU - Hammond, Kyle
AU - Kenyon, Charles
AU - Myer, Gregory D
AU - Madabhushi, Anant
AU - Ganesh, Alexis
PY - 2025
Y1 - 2025
N2 - We performed a prospective, longitudinal investigation to determine whether magnetic resonance imaging (MRI)-based radiomic features from thigh intramuscular fat (IMF) can predict future hamstring strain injury (HSI). Further, we sought to determine if muscle imbalance or injury profile along with radiomics could increase prediction accuracy. This study analyzed IDEAL MRI scans of 93 professional American football players (9 injured, 84 uninjured). Radiomic features relating to textural patterns of IMF were extracted from bilateral hamstring and quadriceps muscles. Feature selection identified non-correlated features that were more strongly associated with future HSI. The K-nearest neighbor classifier was employed to assess the performance of the following models: radiomics of hamstring IMF [Formula: see text] and quadriceps IMF [Formula: see text] muscle imbalance features (Mb) and injury profile features (Mi), as also integrated models for Mr, Mb and [Formula: see text], and integrated Mr and Mb (Mr+b) where [Formula: see text] [Formula: see text] (area under the curve (AUC)=0.79; 95%CI:0.78-0.79) significantly outperformed [Formula: see text] (AUC = 0.69; 95% CI: 0.68-0.70), [Formula: see text] (AUC = 0.74; 95% CI: 0.73-0.75), [Formula: see text] (AUC = 0.68; 95% CI: 0.67-0.69), Mi (AUC = 0.68; 95% CI: 0.68-0.69) as well as Mb (AUC = 0.64; 95% CI: 0.63-0.65). The results indicate that future HSI can be predicted when incorporating radiomics features from hamstrings IMF with muscle imbalance and injury profile data. These novel findings merit further validation in a larger population, one that includes populations of injured and uninjured participants, a limitation acknowledged in current study. This approach could inform future strategies to identify factors to mitigate the risk of HSI not just in elite male athletes but also in athletes of both sexes and any level of participation.
AB - We performed a prospective, longitudinal investigation to determine whether magnetic resonance imaging (MRI)-based radiomic features from thigh intramuscular fat (IMF) can predict future hamstring strain injury (HSI). Further, we sought to determine if muscle imbalance or injury profile along with radiomics could increase prediction accuracy. This study analyzed IDEAL MRI scans of 93 professional American football players (9 injured, 84 uninjured). Radiomic features relating to textural patterns of IMF were extracted from bilateral hamstring and quadriceps muscles. Feature selection identified non-correlated features that were more strongly associated with future HSI. The K-nearest neighbor classifier was employed to assess the performance of the following models: radiomics of hamstring IMF [Formula: see text] and quadriceps IMF [Formula: see text] muscle imbalance features (Mb) and injury profile features (Mi), as also integrated models for Mr, Mb and [Formula: see text], and integrated Mr and Mb (Mr+b) where [Formula: see text] [Formula: see text] (area under the curve (AUC)=0.79; 95%CI:0.78-0.79) significantly outperformed [Formula: see text] (AUC = 0.69; 95% CI: 0.68-0.70), [Formula: see text] (AUC = 0.74; 95% CI: 0.73-0.75), [Formula: see text] (AUC = 0.68; 95% CI: 0.67-0.69), Mi (AUC = 0.68; 95% CI: 0.68-0.69) as well as Mb (AUC = 0.64; 95% CI: 0.63-0.65). The results indicate that future HSI can be predicted when incorporating radiomics features from hamstrings IMF with muscle imbalance and injury profile data. These novel findings merit further validation in a larger population, one that includes populations of injured and uninjured participants, a limitation acknowledged in current study. This approach could inform future strategies to identify factors to mitigate the risk of HSI not just in elite male athletes but also in athletes of both sexes and any level of participation.
M3 - Article
VL - 4
SP - e0001144
JO - Unknown journal
JF - Unknown journal
IS - 12
ER -