Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis)

Fang Fang; Shengmin Sang; Kuang Y. Chen; Alexander Gosslau; Chi Tang Ho; Robert T. Rosen

doi:10.1016/j.foodchem.2004.10.029

Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis)

Fang Fang, Shengmin Sang, Kuang Y. Chen, Alexander Gosslau, Chi Tang Ho, Robert T. Rosen

Rutgers, Stt. Univ. of New Jersey

Research output: Contribution to journal › Article › peer-review

Abstract

Bay leaf belongs to the family Lauraceae, and it is one of the most popular culinary spices in all Western countries. Bay leaf has been used as herbal medicine and has pharmacological activity which includes anti-bacterial, anti-fungal, anti-diabetes and anti-inflammatory effects. The goal of this study was to identify compounds from Bay leaf (Laurus nobilis), which are responsible for inducing apoptosis using bioassay-directed isolation. The isolation of active compounds was carried out in three steps: multiple extractions, fractionation using column chromatography and purification using semi-preparative HPLC. The structure of separated compounds was determined on the basis of ¹H, ¹³C nuclear magnetic resonance data, atmospheric pressure chemical ionization mass spectrometry data, and electron ionization mass spectrometry. Six compounds were identified; all of them are sesquiterpene lactones.

Original language	English
Pages (from-to)	497-501
Number of pages	5
Journal	Food Chemistry
Volume	93
Issue number	3
DOIs	https://doi.org/10.1016/j.foodchem.2004.10.029
State	Published - Dec 2005
Externally published	Yes

Keywords

Bay leaf
HPLC
Laurus nobilis
Mass spectrometry
Sesquiterpene lactones

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.foodchem.2004.10.029

Cite this

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title = "Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis)",

abstract = "Bay leaf belongs to the family Lauraceae, and it is one of the most popular culinary spices in all Western countries. Bay leaf has been used as herbal medicine and has pharmacological activity which includes anti-bacterial, anti-fungal, anti-diabetes and anti-inflammatory effects. The goal of this study was to identify compounds from Bay leaf (Laurus nobilis), which are responsible for inducing apoptosis using bioassay-directed isolation. The isolation of active compounds was carried out in three steps: multiple extractions, fractionation using column chromatography and purification using semi-preparative HPLC. The structure of separated compounds was determined on the basis of 1H, 13C nuclear magnetic resonance data, atmospheric pressure chemical ionization mass spectrometry data, and electron ionization mass spectrometry. Six compounds were identified; all of them are sesquiterpene lactones.",

keywords = "Bay leaf, HPLC, Laurus nobilis, Mass spectrometry, Sesquiterpene lactones",

author = "Fang Fang and Shengmin Sang and Chen, \{Kuang Y.\} and Alexander Gosslau and Ho, \{Chi Tang\} and Rosen, \{Robert T.\}",

year = "2005",

month = dec,

doi = "10.1016/j.foodchem.2004.10.029",

language = "English",

volume = "93",

pages = "497--501",

journal = "Food Chemistry",

issn = "0308-8146",

number = "3",

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TY - JOUR

T1 - Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis)

AU - Fang, Fang

AU - Sang, Shengmin

AU - Chen, Kuang Y.

AU - Gosslau, Alexander

AU - Ho, Chi Tang

AU - Rosen, Robert T.

PY - 2005/12

Y1 - 2005/12

N2 - Bay leaf belongs to the family Lauraceae, and it is one of the most popular culinary spices in all Western countries. Bay leaf has been used as herbal medicine and has pharmacological activity which includes anti-bacterial, anti-fungal, anti-diabetes and anti-inflammatory effects. The goal of this study was to identify compounds from Bay leaf (Laurus nobilis), which are responsible for inducing apoptosis using bioassay-directed isolation. The isolation of active compounds was carried out in three steps: multiple extractions, fractionation using column chromatography and purification using semi-preparative HPLC. The structure of separated compounds was determined on the basis of 1H, 13C nuclear magnetic resonance data, atmospheric pressure chemical ionization mass spectrometry data, and electron ionization mass spectrometry. Six compounds were identified; all of them are sesquiterpene lactones.

AB - Bay leaf belongs to the family Lauraceae, and it is one of the most popular culinary spices in all Western countries. Bay leaf has been used as herbal medicine and has pharmacological activity which includes anti-bacterial, anti-fungal, anti-diabetes and anti-inflammatory effects. The goal of this study was to identify compounds from Bay leaf (Laurus nobilis), which are responsible for inducing apoptosis using bioassay-directed isolation. The isolation of active compounds was carried out in three steps: multiple extractions, fractionation using column chromatography and purification using semi-preparative HPLC. The structure of separated compounds was determined on the basis of 1H, 13C nuclear magnetic resonance data, atmospheric pressure chemical ionization mass spectrometry data, and electron ionization mass spectrometry. Six compounds were identified; all of them are sesquiterpene lactones.

KW - Bay leaf

KW - HPLC

KW - Laurus nobilis

KW - Mass spectrometry

KW - Sesquiterpene lactones

UR - https://www.scopus.com/pages/publications/19544377691

U2 - 10.1016/j.foodchem.2004.10.029

DO - 10.1016/j.foodchem.2004.10.029

M3 - Article

SN - 0308-8146

VL - 93

SP - 497

EP - 501

JO - Food Chemistry

JF - Food Chemistry

IS - 3

ER -

Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis)

Abstract

Keywords

UN SDGs

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