Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis)

Fang Fang; Shengmin Sang; Kuang Y. Chen; Alexander Gosslau; Chi-Tang Ho; Robert T. Rosen

doi:10.1016/j.foodchem.2004.10.029

Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis)

Fang Fang
, Shengmin Sang
, Kuang Y. Chen
, Alexander Gosslau
, Chi-Tang Ho
, Robert T. Rosen

Family and Consumer Sciences

Rutgers, Stt. Univ. of New Jersey

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Bay leaf belongs to the family Lauraceae, and it is one of the most popular culinary spices in all Western countries. Bay leaf has been used as herbal medicine and has pharmacological activity which includes anti-bacterial, anti-fungal, anti-diabetes and anti-inflammatory effects. The goal of this study was to identify compounds from Bay leaf (Laurus nobilis), which are responsible for inducing apoptosis using bioassay-directed isolation. The isolation of active compounds was carried out in three steps: multiple extractions, fractionation using column chromatography and purification using semi-preparative HPLC. The structure of separated compounds was determined on the basis of 1H, 13C nuclear magnetic resonance data, atmospheric pressure chemical ionization mass spectrometry data, and electron ionization mass spectrometry. Six compounds were identified; all of them are sesquiterpene lactones. © 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	497-501
Number of pages	5
Journal	Food Chemistry
Volume	93
Issue number	3
DOIs	https://doi.org/10.1016/j.foodchem.2004.10.029
State	Published - Dec 1 2005

Keywords

Bay leaf
HPLC
Laurus nobilis
Mass spectrometry
Sesquiterpene lactones

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.foodchem.2004.10.029

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title = "Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis)",

abstract = "Bay leaf belongs to the family Lauraceae, and it is one of the most popular culinary spices in all Western countries. Bay leaf has been used as herbal medicine and has pharmacological activity which includes anti-bacterial, anti-fungal, anti-diabetes and anti-inflammatory effects. The goal of this study was to identify compounds from Bay leaf (Laurus nobilis), which are responsible for inducing apoptosis using bioassay-directed isolation. The isolation of active compounds was carried out in three steps: multiple extractions, fractionation using column chromatography and purification using semi-preparative HPLC. The structure of separated compounds was determined on the basis of 1H, 13C nuclear magnetic resonance data, atmospheric pressure chemical ionization mass spectrometry data, and electron ionization mass spectrometry. Six compounds were identified; all of them are sesquiterpene lactones. {\textcopyright} 2004 Elsevier Ltd. All rights reserved.",

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AU - Fang, Fang

AU - Sang, Shengmin

AU - Chen, Kuang Y.

AU - Gosslau, Alexander

AU - Ho, Chi-Tang

AU - Rosen, Robert T.

PY - 2005/12/1

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KW - Bay leaf

KW - HPLC

KW - Laurus nobilis

KW - Mass spectrometry

KW - Sesquiterpene lactones

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JF - Food Chemistry

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ER -

Isolation and identification of cytotoxic compounds from Bay leaf (Laurus nobilis)

Abstract

Keywords

UN SDGs

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