TY - JOUR
T1 - Kefir prevented excess fat accumulation in diet-induced obese mice
AU - Choi, Jae-Woo
AU - Kang, Hye Won
AU - Lim, Won-Chul
AU - Kim, Mi-Kyoung
AU - Lee, In-Young
AU - Cho, Hong-Yon
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Excessive body fat accumulation can result in obesity, which is a serious health concern. Kefir, a probiotic, has recently shown possible health benefits in fighting obesity. This study investigated the inhibitory effects of 0.1 and 0.2% kefir powder on fat accumulation in adipose and liver tissues of high-fat diet (HFD)-induced obese mice. Kefir reduced body weight and epididymal fat pad weight and decreased adipocyte diameters in HFD-induced obese mice. This was supported by decreased expression of genes related to adipogenesis and lipogenesis as well as reduced proinflammatory marker levels in epididymal fat. Along with reduced hepatic triacylglycerol concentrations and serum alanine transaminase and aspartate transaminase activities, genes related to lipogenesis and fatty acid oxidation were downregulated and upregulated, respectively, in liver tissue. Kefir also decreased serum triacylglycerol, total cholesterol, and low-density lipoprotein- cholesterol concentrations. Overall, kefir has the potential to prevent obesity.
AB - Excessive body fat accumulation can result in obesity, which is a serious health concern. Kefir, a probiotic, has recently shown possible health benefits in fighting obesity. This study investigated the inhibitory effects of 0.1 and 0.2% kefir powder on fat accumulation in adipose and liver tissues of high-fat diet (HFD)-induced obese mice. Kefir reduced body weight and epididymal fat pad weight and decreased adipocyte diameters in HFD-induced obese mice. This was supported by decreased expression of genes related to adipogenesis and lipogenesis as well as reduced proinflammatory marker levels in epididymal fat. Along with reduced hepatic triacylglycerol concentrations and serum alanine transaminase and aspartate transaminase activities, genes related to lipogenesis and fatty acid oxidation were downregulated and upregulated, respectively, in liver tissue. Kefir also decreased serum triacylglycerol, total cholesterol, and low-density lipoprotein- cholesterol concentrations. Overall, kefir has the potential to prevent obesity.
KW - Kefir
KW - Liver
KW - Obesity
KW - White adipose tissue
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85018612383&origin=inward
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85018612383&origin=inward
U2 - 10.1080/09168451.2016.1258984
DO - 10.1080/09168451.2016.1258984
M3 - Article
C2 - 28110622
SN - 0916-8451
VL - 81
SP - 958
EP - 965
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 5
ER -
