TY - GEN
T1 - Micro-Computed Tomography to Finite Element Analysis of In Vivo Biodegradable Magnesium-Alloy Screw and Surrounding Bone in Rabbit Femurs
AU - Williams, Adrienne F
AU - Sankar, Jagannathan
AU - McCullough, Matthew B
N1 - Publisher Copyright:
Copyright © 2015 by ASME.
PY - 2015
Y1 - 2015
N2 - Magnesium (Mg) and its alloys are attractive orthopedic biomaterials because of their degradability and mechanical properties, which are similar to bone's. Characterizing the mechanical changes and interactions of these promising degradable biomaterials and the host environment (bone) is essential to their success in orthopedic devices. The objective of this study was to develop a protocol to evaluate in vivo biodegradable Mg-alloy screws and surrounding new and cancellous bone in rabbit femurs over time, using high resolution micro-computed tomography (micro-CT) images and the finite element method. Micro-CT was used to visually evaluate bone remodeling and degradation of Mg-alloy screws that were implanted in rabbit femoral condyles for 2, 4, 12, 24, 36 and 52 weeks. Over time, the degradation product around the device and the remainder of the intact core was observed. Scans were segmented into bone, degradation/corrosion products and nondegraded device, then reconstructed into 3D volumes. These volumes were meshed and assigned material properties based on CT data. The meshed volumes were exported to finite element software and analyzed in a virtual environment. Several foundational observations were made about animal modeling of in vivo degrading magnesium devices with a micro-CT to FEA protocol.
AB - Magnesium (Mg) and its alloys are attractive orthopedic biomaterials because of their degradability and mechanical properties, which are similar to bone's. Characterizing the mechanical changes and interactions of these promising degradable biomaterials and the host environment (bone) is essential to their success in orthopedic devices. The objective of this study was to develop a protocol to evaluate in vivo biodegradable Mg-alloy screws and surrounding new and cancellous bone in rabbit femurs over time, using high resolution micro-computed tomography (micro-CT) images and the finite element method. Micro-CT was used to visually evaluate bone remodeling and degradation of Mg-alloy screws that were implanted in rabbit femoral condyles for 2, 4, 12, 24, 36 and 52 weeks. Over time, the degradation product around the device and the remainder of the intact core was observed. Scans were segmented into bone, degradation/corrosion products and nondegraded device, then reconstructed into 3D volumes. These volumes were meshed and assigned material properties based on CT data. The meshed volumes were exported to finite element software and analyzed in a virtual environment. Several foundational observations were made about animal modeling of in vivo degrading magnesium devices with a micro-CT to FEA protocol.
M3 - Conference contribution
BT - Unknown book
ER -