Nanoelectrodes to differentiate adipose derived stem cells into neural lineage

This paper reports on a minimal growth factor and clinical translation friendly methodology using micromachined penetrating nanoelectrodes to differentiate Adipose Derived Stem Cells (ADSCs) into neuronal lineage. Electrical stimulus is delivered via penetrating nanoelectrodes to differentiate ADSCs toward neuronal lineage with minimal use of conventional growth factors, genetic manipulators, cytokines or other chemical reagents. The paper also reports on the time dynamics of cell penetration process using the nanoelectrodes.