Optical and MRI multifunctional nanoprobe for targeting gliomas

Omid Veiseh; Conroy Sun; Jonathan Gunn; Nathan Kohler; Patrik Gabikian; Donghoon Lee; Narayan Bhattarai; Richard Ellenbogen; Raymond Sze; Andrew Hallahan; Jim Olson; Miqin Zhang

doi:10.1021/nl0502569

Optical and MRI multifunctional nanoprobe for targeting gliomas

Omid Veiseh, Conroy Sun, Jonathan Gunn, Nathan Kohler, Patrik Gabikian, Donghoon Lee, Narayan Bhattarai, Richard Ellenbogen, Raymond Sze, Andrew Hallahan, Jim Olson, Miqin Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

A multifunctional nanoprobe capable of targeting glioma cells, detectable by both magnetic resonance imaging and fluorescence microscopy, was developed. The nanoprobe was synthesized by coating Iron oxide nanoparticles with covalently bound bifunctional poly(ethylene glycol) (PEG) polymer, which were subsequently functionalized with chlorotoxin and the near-infrared fluorescing molecule Cy5.5. Both MR imaging and fluorescence microscopy showed significant preferential uptake of the nanoparticle conjugates by glioma cells. Such a nanoprobe could potentially be used to image resections of glioma brain tumors in real time and to correlate preoperative diagnostic images with intraoperative pathology at cellular-level resolution.

Original language	English
Pages (from-to)	1003-1008
Number of pages	6
Journal	Nano Letters
Volume	5
Issue number	6
DOIs	https://doi.org/10.1021/nl0502569
State	Published - Jun 2005
Externally published	Yes

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10.1021/nl0502569

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title = "Optical and MRI multifunctional nanoprobe for targeting gliomas",

abstract = "A multifunctional nanoprobe capable of targeting glioma cells, detectable by both magnetic resonance imaging and fluorescence microscopy, was developed. The nanoprobe was synthesized by coating Iron oxide nanoparticles with covalently bound bifunctional poly(ethylene glycol) (PEG) polymer, which were subsequently functionalized with chlorotoxin and the near-infrared fluorescing molecule Cy5.5. Both MR imaging and fluorescence microscopy showed significant preferential uptake of the nanoparticle conjugates by glioma cells. Such a nanoprobe could potentially be used to image resections of glioma brain tumors in real time and to correlate preoperative diagnostic images with intraoperative pathology at cellular-level resolution.",

author = "Omid Veiseh and Conroy Sun and Jonathan Gunn and Nathan Kohler and Patrik Gabikian and Donghoon Lee and Narayan Bhattarai and Richard Ellenbogen and Raymond Sze and Andrew Hallahan and Jim Olson and Miqin Zhang",

year = "2005",

month = jun,

doi = "10.1021/nl0502569",

language = "English",

volume = "5",

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journal = "Nano Letters",

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TY - JOUR

T1 - Optical and MRI multifunctional nanoprobe for targeting gliomas

AU - Veiseh, Omid

AU - Sun, Conroy

AU - Gunn, Jonathan

AU - Kohler, Nathan

AU - Gabikian, Patrik

AU - Lee, Donghoon

AU - Bhattarai, Narayan

AU - Ellenbogen, Richard

AU - Sze, Raymond

AU - Hallahan, Andrew

AU - Olson, Jim

AU - Zhang, Miqin

PY - 2005/6

Y1 - 2005/6

N2 - A multifunctional nanoprobe capable of targeting glioma cells, detectable by both magnetic resonance imaging and fluorescence microscopy, was developed. The nanoprobe was synthesized by coating Iron oxide nanoparticles with covalently bound bifunctional poly(ethylene glycol) (PEG) polymer, which were subsequently functionalized with chlorotoxin and the near-infrared fluorescing molecule Cy5.5. Both MR imaging and fluorescence microscopy showed significant preferential uptake of the nanoparticle conjugates by glioma cells. Such a nanoprobe could potentially be used to image resections of glioma brain tumors in real time and to correlate preoperative diagnostic images with intraoperative pathology at cellular-level resolution.

AB - A multifunctional nanoprobe capable of targeting glioma cells, detectable by both magnetic resonance imaging and fluorescence microscopy, was developed. The nanoprobe was synthesized by coating Iron oxide nanoparticles with covalently bound bifunctional poly(ethylene glycol) (PEG) polymer, which were subsequently functionalized with chlorotoxin and the near-infrared fluorescing molecule Cy5.5. Both MR imaging and fluorescence microscopy showed significant preferential uptake of the nanoparticle conjugates by glioma cells. Such a nanoprobe could potentially be used to image resections of glioma brain tumors in real time and to correlate preoperative diagnostic images with intraoperative pathology at cellular-level resolution.

UR - https://www.scopus.com/pages/publications/21644450671

U2 - 10.1021/nl0502569

DO - 10.1021/nl0502569

M3 - Article

SN - 1530-6984

VL - 5

SP - 1003

EP - 1008

JO - Nano Letters

JF - Nano Letters

IS - 6

ER -

Optical and MRI multifunctional nanoprobe for targeting gliomas

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