Penetrating nanoelectrodes for stimulation of cells

This paper reports on the development of two penetrating nanoelectrode geometries, namely nanopillars and nanofins, to interface with cells. Electrical stimuli can be delivered via these penetrating nanoelectrodes to stimulate of cells, including Adipose Derived Stem Cells (ADSCs). This approach enables the development of a clinical translation friendly methodology to differentiate ADSCs into neuronal lineage that is free of conventional growth factors, genetic manipulators, cytokines or other chemical reagents. The paper also reports on the time dynamics of cell penetration process using nanoelectrodes.