Performance of Canonical Correlation Forest in Phosphorylation Site Predictions

Daniel T. Ocansey, Marvin Aidoo, Marwan Bikdash, Hamid D. Ismail, Clarence White, Robert H. Newman, B. K.C. Dukka

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Protein phosphorylation is among the most widely used regulatory mechanisms in eukaryotes. In recent years, several phosphorylation site prediction tools have been developed to identify phosphorylation sites in silico. However, there are still ways to improve the performance of these methods. Here, we report the development of a new predictor, termed Canonical Correlation Forest-based Phosphosite (CCF-Phos) predictor, to predict putative phosphorylation sites on a given protein. The CCF-Phos was evaluated using both 10-fold cross-validation and an independent dataset. During these analyses, CCF-Phos compared favorably to other popular mammalian phosphosite prediction methods.

Original languageEnglish
Title of host publicationSoutheastcon 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538661338
DOIs
StatePublished - Oct 1 2018
Event2018 IEEE Southeastcon, Southeastcon 2018 - St. Petersburg, United States
Duration: Apr 19 2018Apr 22 2018

Publication series

NameConference Proceedings - IEEE SOUTHEASTCON
Volume2018-April
ISSN (Print)1091-0050
ISSN (Electronic)1558-058X

Conference

Conference2018 IEEE Southeastcon, Southeastcon 2018
Country/TerritoryUnited States
CitySt. Petersburg
Period04/19/1804/22/18

Keywords

  • CCF
  • RF
  • phosphorylation
  • protein sequence

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