TY - JOUR
T1 - PH-responsive polymeric micelles with core-shell-corona architectures as intracellular anti-cancer drug carriers
AU - Bastakoti, Bishnu Prasad
AU - Liao, Shih-Hsiang
AU - Inoue, Masamichi
AU - Yusa, Shin-Ichi
AU - Imura, Masataka
AU - Nakashima, Kenichi
AU - Wu, Kevin C.-W.
AU - Yamauchi, Yusuke
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Polymeric micelles with core-shell-corona nanoarchitecture were designed for intracellular therapeutic anti-cancer drug carriers. Poly(styrene-b-acrylic acid-b-ethylene glycol) (PS-b-PAA-b-PEG) asymmetric triblock copolymer underwent self-assembly in aqueous solution to form spherical micelles with hydrophobic PS core, anionic PAA shell and hydrophilic PEG corona. The anti-cancer drug (doxorubicin, DOX) was successfully incorporated into the polymeric micelles. The in vitro release experiment confirmed that the release of DOX from the micelles was inhibited at pH 7.4. In contrast, an accelerated release of DOX was observed at mildly acidic conditions such as pH 4.5. The excellent biocompatibility of our PS-b-PAA-b-PEG-based micelles made the synthesized nano-carrier best suited for the delivery of anti-cancer drugs. © 2013 National Institute for Materials Science.
AB - Polymeric micelles with core-shell-corona nanoarchitecture were designed for intracellular therapeutic anti-cancer drug carriers. Poly(styrene-b-acrylic acid-b-ethylene glycol) (PS-b-PAA-b-PEG) asymmetric triblock copolymer underwent self-assembly in aqueous solution to form spherical micelles with hydrophobic PS core, anionic PAA shell and hydrophilic PEG corona. The anti-cancer drug (doxorubicin, DOX) was successfully incorporated into the polymeric micelles. The in vitro release experiment confirmed that the release of DOX from the micelles was inhibited at pH 7.4. In contrast, an accelerated release of DOX was observed at mildly acidic conditions such as pH 4.5. The excellent biocompatibility of our PS-b-PAA-b-PEG-based micelles made the synthesized nano-carrier best suited for the delivery of anti-cancer drugs. © 2013 National Institute for Materials Science.
KW - anti-cancer drug carrier
KW - block copolymer
KW - core-shell-corona micelle
KW - doxorubicin
KW - frozen micelle
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884794462&origin=inward
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84884794462&origin=inward
U2 - 10.1088/1468-6996/14/4/044402
DO - 10.1088/1468-6996/14/4/044402
M3 - Article
SN - 1468-6996
VL - 14
JO - Science and Technology of Advanced Materials
JF - Science and Technology of Advanced Materials
IS - 4
M1 - 044402
ER -
