Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARα)

Hye Won Kang; Keishi Kanno; Erez F. Scapa; David E. Cohen

doi:10.1016/j.bbalip.2009.12.013

Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARα)

Hye Won Kang, Keishi Kanno, Erez F. Scapa, David E. Cohen

Harvard Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Phosphatidylcholine transfer protein (PC-TP, a.k.a. StarD2) is abundantly expressed in liver and is regulated by PPARα. When fed the synthetic PPARα ligand fenofibrate, Pctp^-/- mice exhibited altered lipid and glucose metabolism. Microarray profiling of livers from fenofibrate fed wild type and Pctp^-/- mice revealed differential expression of a broad array of metabolic genes, as well as their regulatory transcription factors. PC-TP expression in cell culture controlled the activities of both PPARα and HNF4α, suggesting that the mechanism by which it modulates hepatic metabolism is at least in part via activation of transcription factors that govern nutrient homeostasis.

Original language	English
Pages (from-to)	496-502
Number of pages	7
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	1801
Issue number	4
DOIs	https://doi.org/10.1016/j.bbalip.2009.12.013
State	Published - Apr 2010
Externally published	Yes

Keywords

Fibrate drug
Gene transcription
Glucose
Lipid
Microarray
START domain

Access to Document

10.1016/j.bbalip.2009.12.013

Cite this

@article{1a6091294a1645fca44870bd09d31d35,

title = "Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARα)",

abstract = "Phosphatidylcholine transfer protein (PC-TP, a.k.a. StarD2) is abundantly expressed in liver and is regulated by PPARα. When fed the synthetic PPARα ligand fenofibrate, Pctp-/- mice exhibited altered lipid and glucose metabolism. Microarray profiling of livers from fenofibrate fed wild type and Pctp-/- mice revealed differential expression of a broad array of metabolic genes, as well as their regulatory transcription factors. PC-TP expression in cell culture controlled the activities of both PPARα and HNF4α, suggesting that the mechanism by which it modulates hepatic metabolism is at least in part via activation of transcription factors that govern nutrient homeostasis.",

keywords = "Fibrate drug, Gene transcription, Glucose, Lipid, Microarray, START domain",

author = "Kang, \{Hye Won\} and Keishi Kanno and Scapa, \{Erez F.\} and Cohen, \{David E.\}",

year = "2010",

month = apr,

doi = "10.1016/j.bbalip.2009.12.013",

language = "English",

volume = "1801",

pages = "496--502",

journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",

issn = "1388-1981",

number = "4",

}

Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARα). / Kang, Hye Won; Kanno, Keishi; Scapa, Erez F. et al.
In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Vol. 1801, No. 4, 04.2010, p. 496-502.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARα)

AU - Kang, Hye Won

AU - Kanno, Keishi

AU - Scapa, Erez F.

AU - Cohen, David E.

PY - 2010/4

Y1 - 2010/4

N2 - Phosphatidylcholine transfer protein (PC-TP, a.k.a. StarD2) is abundantly expressed in liver and is regulated by PPARα. When fed the synthetic PPARα ligand fenofibrate, Pctp-/- mice exhibited altered lipid and glucose metabolism. Microarray profiling of livers from fenofibrate fed wild type and Pctp-/- mice revealed differential expression of a broad array of metabolic genes, as well as their regulatory transcription factors. PC-TP expression in cell culture controlled the activities of both PPARα and HNF4α, suggesting that the mechanism by which it modulates hepatic metabolism is at least in part via activation of transcription factors that govern nutrient homeostasis.

AB - Phosphatidylcholine transfer protein (PC-TP, a.k.a. StarD2) is abundantly expressed in liver and is regulated by PPARα. When fed the synthetic PPARα ligand fenofibrate, Pctp-/- mice exhibited altered lipid and glucose metabolism. Microarray profiling of livers from fenofibrate fed wild type and Pctp-/- mice revealed differential expression of a broad array of metabolic genes, as well as their regulatory transcription factors. PC-TP expression in cell culture controlled the activities of both PPARα and HNF4α, suggesting that the mechanism by which it modulates hepatic metabolism is at least in part via activation of transcription factors that govern nutrient homeostasis.

KW - Fibrate drug

KW - Gene transcription

KW - Glucose

KW - Lipid

KW - Microarray

KW - START domain

UR - https://www.scopus.com/pages/publications/76549119341

U2 - 10.1016/j.bbalip.2009.12.013

DO - 10.1016/j.bbalip.2009.12.013

M3 - Article

SN - 1388-1981

VL - 1801

SP - 496

EP - 502

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

IS - 4

ER -

Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARα)

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this