TY - JOUR
T1 - Relationship between systemic inflammation and delayed-type hypersensitivity response to Candida antigen in older adults
AU - Pence, Brandt D.
AU - Lowder, Thomas W.
AU - Keylock, K. Todd
AU - Potter, Victoria J. Vieira
AU - Cook, Marc D
AU - McAuley, Edward
AU - Woods, Jeffrey A.
PY - 2012/5/2
Y1 - 2012/5/2
N2 - Research has shown that aging is associated with increased systemic inflammation as well as a reduction in the strength of immune responses. However, little evidence exists linking the decrease in cell-mediated immunity in older adults with other health parameters. We sought to examine the relationship between cell-mediated immunity as measured in vivo by the delayed-type hypersensitivity (DTH) response to candida antigen and demographic and physiological variables in older (65-80 y.o.) adults. Candida antigen response was not related to gender or obesity, or to a number of other physiological variables including fitness and body composition. However, positive responders had significantly lower serum C-reactive protein levels (CRP, p<0.05) vs. non-responders. Furthermore, subjects with CRP<4.75 mg•L-1 had greater odds of developing a positive response compared to those with CRP>4.75 mg•L-1. Therefore, positive responses to candida antigen in older adults appears to be related to lower levels of systemic inflammation. © 2012 Pence et al.
AB - Research has shown that aging is associated with increased systemic inflammation as well as a reduction in the strength of immune responses. However, little evidence exists linking the decrease in cell-mediated immunity in older adults with other health parameters. We sought to examine the relationship between cell-mediated immunity as measured in vivo by the delayed-type hypersensitivity (DTH) response to candida antigen and demographic and physiological variables in older (65-80 y.o.) adults. Candida antigen response was not related to gender or obesity, or to a number of other physiological variables including fitness and body composition. However, positive responders had significantly lower serum C-reactive protein levels (CRP, p<0.05) vs. non-responders. Furthermore, subjects with CRP<4.75 mg•L-1 had greater odds of developing a positive response compared to those with CRP>4.75 mg•L-1. Therefore, positive responses to candida antigen in older adults appears to be related to lower levels of systemic inflammation. © 2012 Pence et al.
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U2 - 10.1371/journal.pone.0036403
DO - 10.1371/journal.pone.0036403
M3 - Article
C2 - 22567155
SN - 1932-6203
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 5
M1 - e36403
ER -
