Selection on stress resistance increases longevity in Drosophila melanogaster

Michael R. Rose; Linh N. Vu; Sung U. Park; Joseph L. Graves

doi:10.1016/0531-5565(92)90048-5

Selection on stress resistance increases longevity in Drosophila melanogaster

Michael R. Rose
, Linh N. Vu
, Sung U. Park
, Joseph L. Graves

Biology

Research output: Contribution to journal › Article

Abstract

Tests for the causal involvement of specific physiological mechanisms in the control of aging require evidence that these mechanisms can be used to increase longevity or reproductive lifespan. Selection for later reproduction in Drosophila has been shown to lead to increased longevity, as well as increased resistance to starvation and desiccation stresses. Selection for increased resistance to starvation and desiccation in Drosophila melanogaster is here shown to lead to increased longevity, indicating that alleles that increase stressresistance also may increase longevity. The responses of desiccation and starvation resistance to selection are partly independent of each other, indicating a multiplicity of physiological mechanisms involved in selectively postponed aging, and thus aging in general. © 1992.

Original language	English
Journal	Experimental Gerontology
Volume	27
Issue number	Issue 2
DOIs	https://doi.org/10.1016/0531-5565(92)90048-5
State	Published - 1992

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title = "Selection on stress resistance increases longevity in Drosophila melanogaster",

abstract = "Tests for the causal involvement of specific physiological mechanisms in the control of aging require evidence that these mechanisms can be used to increase longevity or reproductive lifespan. Selection for later reproduction in Drosophila has been shown to lead to increased longevity, as well as increased resistance to starvation and desiccation stresses. Selection for increased resistance to starvation and desiccation in Drosophila melanogaster is here shown to lead to increased longevity, indicating that alleles that increase stressresistance also may increase longevity. The responses of desiccation and starvation resistance to selection are partly independent of each other, indicating a multiplicity of physiological mechanisms involved in selectively postponed aging, and thus aging in general. {\textcopyright} 1992.",

author = "Rose, \{Michael R.\} and Vu, \{Linh N.\} and Park, \{Sung U.\} and Graves, \{Joseph L.\}",

year = "1992",

doi = "10.1016/0531-5565(92)90048-5",

language = "English",

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journal = "Experimental Gerontology",

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T1 - Selection on stress resistance increases longevity in Drosophila melanogaster

AU - Rose, Michael R.

AU - Vu, Linh N.

AU - Park, Sung U.

AU - Graves, Joseph L.

PY - 1992

Y1 - 1992

N2 - Tests for the causal involvement of specific physiological mechanisms in the control of aging require evidence that these mechanisms can be used to increase longevity or reproductive lifespan. Selection for later reproduction in Drosophila has been shown to lead to increased longevity, as well as increased resistance to starvation and desiccation stresses. Selection for increased resistance to starvation and desiccation in Drosophila melanogaster is here shown to lead to increased longevity, indicating that alleles that increase stressresistance also may increase longevity. The responses of desiccation and starvation resistance to selection are partly independent of each other, indicating a multiplicity of physiological mechanisms involved in selectively postponed aging, and thus aging in general. © 1992.

AB - Tests for the causal involvement of specific physiological mechanisms in the control of aging require evidence that these mechanisms can be used to increase longevity or reproductive lifespan. Selection for later reproduction in Drosophila has been shown to lead to increased longevity, as well as increased resistance to starvation and desiccation stresses. Selection for increased resistance to starvation and desiccation in Drosophila melanogaster is here shown to lead to increased longevity, indicating that alleles that increase stressresistance also may increase longevity. The responses of desiccation and starvation resistance to selection are partly independent of each other, indicating a multiplicity of physiological mechanisms involved in selectively postponed aging, and thus aging in general. © 1992.

UR - https://dx.doi.org/10.1016/0531-5565(92)90048-5

U2 - 10.1016/0531-5565(92)90048-5

DO - 10.1016/0531-5565(92)90048-5

M3 - Article

VL - 27

JO - Experimental Gerontology

JF - Experimental Gerontology

IS - Issue 2

ER -

Selection on stress resistance increases longevity in Drosophila melanogaster

Abstract

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