Stimuli-induced core-corona inversion of micelle of poly (acrylic acid)-block-Poly(N-isopropylacrylamide) and its application in drug delivery

Bishnu P Bastakoti; Sudhina Guragain; Kenichi Nakashima; Yusuke Yamauchi

doi:10.1002/macp.201400440

Stimuli-induced core-corona inversion of micelle of poly (acrylic acid)-block-Poly(N-isopropylacrylamide) and its application in drug delivery

Bishnu P Bastakoti
, Sudhina Guragain
, Kenichi Nakashima
, Yusuke Yamauchi

Chemistry

National Institute for Materials Science
Saga University
Waseda University

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Core-corona inversion of micelles of diblock copolymer poly(acrylic acid)-block-poly(N-isopropylacrylamide) (PAA-b-PNIPAM), has been successfully realized by switching either pH or temperature. The strong interaction of doxorubicin with the PAA block and the pH-sensitive drug release from the polymer make the system very useful as a controlled drug delivery system. The encapsulation of hydrophobic Nile Red molecules above the lower critical solution temperature of PNIPAM suggests that this polymer may be useful for removing hydrophobic pollutants.

Original language	English
Pages (from-to)	287-291
Number of pages	5
Journal	Macromolecular Chemistry and Physics
Volume	216
Issue number	3
DOIs	https://doi.org/10.1002/macp.201400440
State	Published - Feb 1 2015

Keywords

Block copolymers
Core-corona inversion
Drug carriers
Polymeric micelles
Schizophrenic micelles

Access to Document

10.1002/macp.201400440

Cite this

@article{274fb7baf7284fe8a0bc3aab947c80f8,

title = "Stimuli-induced core-corona inversion of micelle of poly (acrylic acid)-block-Poly(N-isopropylacrylamide) and its application in drug delivery",

abstract = "Core-corona inversion of micelles of diblock copolymer poly(acrylic acid)-block-poly(N-isopropylacrylamide) (PAA-b-PNIPAM), has been successfully realized by switching either pH or temperature. The strong interaction of doxorubicin with the PAA block and the pH-sensitive drug release from the polymer make the system very useful as a controlled drug delivery system. The encapsulation of hydrophobic Nile Red molecules above the lower critical solution temperature of PNIPAM suggests that this polymer may be useful for removing hydrophobic pollutants.",

keywords = "Block copolymers, Core-corona inversion, Drug carriers, Polymeric micelles, Schizophrenic micelles",

author = "Bastakoti, \{Bishnu P\} and Sudhina Guragain and Kenichi Nakashima and Yusuke Yamauchi",

year = "2015",

month = feb,

day = "1",

doi = "10.1002/macp.201400440",

language = "English",

volume = "216",

pages = "287--291",

journal = "Macromolecular Chemistry and Physics",

issn = "1022-1352",

publisher = "Wiley-VCH [email protected]",

number = "3",

}

TY - JOUR

T1 - Stimuli-induced core-corona inversion of micelle of poly (acrylic acid)-block-Poly(N-isopropylacrylamide) and its application in drug delivery

AU - Bastakoti, Bishnu P

AU - Guragain, Sudhina

AU - Nakashima, Kenichi

AU - Yamauchi, Yusuke

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Core-corona inversion of micelles of diblock copolymer poly(acrylic acid)-block-poly(N-isopropylacrylamide) (PAA-b-PNIPAM), has been successfully realized by switching either pH or temperature. The strong interaction of doxorubicin with the PAA block and the pH-sensitive drug release from the polymer make the system very useful as a controlled drug delivery system. The encapsulation of hydrophobic Nile Red molecules above the lower critical solution temperature of PNIPAM suggests that this polymer may be useful for removing hydrophobic pollutants.

AB - Core-corona inversion of micelles of diblock copolymer poly(acrylic acid)-block-poly(N-isopropylacrylamide) (PAA-b-PNIPAM), has been successfully realized by switching either pH or temperature. The strong interaction of doxorubicin with the PAA block and the pH-sensitive drug release from the polymer make the system very useful as a controlled drug delivery system. The encapsulation of hydrophobic Nile Red molecules above the lower critical solution temperature of PNIPAM suggests that this polymer may be useful for removing hydrophobic pollutants.

KW - Block copolymers

KW - Core-corona inversion

KW - Drug carriers

KW - Polymeric micelles

KW - Schizophrenic micelles

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84922949700&origin=inward

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84922949700&origin=inward

U2 - 10.1002/macp.201400440

DO - 10.1002/macp.201400440

M3 - Article

SN - 1022-1352

VL - 216

SP - 287

EP - 291

JO - Macromolecular Chemistry and Physics

JF - Macromolecular Chemistry and Physics

IS - 3

ER -

Stimuli-induced core-corona inversion of micelle of poly (acrylic acid)-block-Poly(N-isopropylacrylamide) and its application in drug delivery

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this