TY - JOUR
T1 - Stimuli-induced core-corona inversion of micelle of poly (acrylic acid)-block-Poly(N-isopropylacrylamide) and its application in drug delivery
AU - Bastakoti, Bishnu P
AU - Guragain, Sudhina
AU - Nakashima, Kenichi
AU - Yamauchi, Yusuke
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Core-corona inversion of micelles of diblock copolymer poly(acrylic acid)-block-poly(N-isopropylacrylamide) (PAA-b-PNIPAM), has been successfully realized by switching either pH or temperature. The strong interaction of doxorubicin with the PAA block and the pH-sensitive drug release from the polymer make the system very useful as a controlled drug delivery system. The encapsulation of hydrophobic Nile Red molecules above the lower critical solution temperature of PNIPAM suggests that this polymer may be useful for removing hydrophobic pollutants.
AB - Core-corona inversion of micelles of diblock copolymer poly(acrylic acid)-block-poly(N-isopropylacrylamide) (PAA-b-PNIPAM), has been successfully realized by switching either pH or temperature. The strong interaction of doxorubicin with the PAA block and the pH-sensitive drug release from the polymer make the system very useful as a controlled drug delivery system. The encapsulation of hydrophobic Nile Red molecules above the lower critical solution temperature of PNIPAM suggests that this polymer may be useful for removing hydrophobic pollutants.
KW - Block copolymers
KW - Core-corona inversion
KW - Drug carriers
KW - Polymeric micelles
KW - Schizophrenic micelles
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U2 - 10.1002/macp.201400440
DO - 10.1002/macp.201400440
M3 - Article
SN - 1022-1352
VL - 216
SP - 287
EP - 291
JO - Macromolecular Chemistry and Physics
JF - Macromolecular Chemistry and Physics
IS - 3
ER -