Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry

Xi Shao; Xiaoxin Chen; Vladimir Badmaev; Chi-Tang Ho; Shengmin Sang

doi:10.1002/rcm.4579

Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry

Xi Shao
, Xiaoxin Chen
, Vladimir Badmaev
, Chi-Tang Ho
, Shengmin Sang

North Carolina Agricultural and Technical State University
North Carolina Central University
Rutgers, Stt. Univ. of New Jersey
Department of Food Science
Laboratory of Applied Pharmacology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the present study, we identified nine novel mouse urinary pterostilbene metabolites, pterostilbene glucuronide, pterostilbene sulfate, mono-demethylated pterostilbene glucuronide, mono-demethylated pterostilbene sulfate, mono-hydroxylated pterostilbene, mono-hydroxylated pterostilbene glucuronide, mono-hydroxylated pterostilbene sulfate, and mono-hydroxylated pterostilbene glucuronide sulfate, using liquid chromatography/atmospheric pressure chemical ionization and electrospray ionization tandem mass spectrometry. The structures of these metabolites were confirmed by analyzing the MSn (n=1-3) spectra. To our knowledge, this is the first report of the identification of urinary metabolites of pterostilbene in mice. © 2010 John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	1770-1778
Number of pages	9
Journal	Rapid Communications in Mass Spectrometry
Volume	24
Issue number	12
DOIs	https://doi.org/10.1002/rcm.4579
State	Published - Jan 1 2010

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abstract = "Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the present study, we identified nine novel mouse urinary pterostilbene metabolites, pterostilbene glucuronide, pterostilbene sulfate, mono-demethylated pterostilbene glucuronide, mono-demethylated pterostilbene sulfate, mono-hydroxylated pterostilbene, mono-hydroxylated pterostilbene glucuronide, mono-hydroxylated pterostilbene sulfate, and mono-hydroxylated pterostilbene glucuronide sulfate, using liquid chromatography/atmospheric pressure chemical ionization and electrospray ionization tandem mass spectrometry. The structures of these metabolites were confirmed by analyzing the MSn (n=1-3) spectra. To our knowledge, this is the first report of the identification of urinary metabolites of pterostilbene in mice. {\textcopyright} 2010 John Wiley \& Sons, Ltd.",

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AU - Shao, Xi

AU - Chen, Xiaoxin

AU - Badmaev, Vladimir

AU - Ho, Chi-Tang

AU - Sang, Shengmin

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the present study, we identified nine novel mouse urinary pterostilbene metabolites, pterostilbene glucuronide, pterostilbene sulfate, mono-demethylated pterostilbene glucuronide, mono-demethylated pterostilbene sulfate, mono-hydroxylated pterostilbene, mono-hydroxylated pterostilbene glucuronide, mono-hydroxylated pterostilbene sulfate, and mono-hydroxylated pterostilbene glucuronide sulfate, using liquid chromatography/atmospheric pressure chemical ionization and electrospray ionization tandem mass spectrometry. The structures of these metabolites were confirmed by analyzing the MSn (n=1-3) spectra. To our knowledge, this is the first report of the identification of urinary metabolites of pterostilbene in mice. © 2010 John Wiley & Sons, Ltd.

AB - Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the present study, we identified nine novel mouse urinary pterostilbene metabolites, pterostilbene glucuronide, pterostilbene sulfate, mono-demethylated pterostilbene glucuronide, mono-demethylated pterostilbene sulfate, mono-hydroxylated pterostilbene, mono-hydroxylated pterostilbene glucuronide, mono-hydroxylated pterostilbene sulfate, and mono-hydroxylated pterostilbene glucuronide sulfate, using liquid chromatography/atmospheric pressure chemical ionization and electrospray ionization tandem mass spectrometry. The structures of these metabolites were confirmed by analyzing the MSn (n=1-3) spectra. To our knowledge, this is the first report of the identification of urinary metabolites of pterostilbene in mice. © 2010 John Wiley & Sons, Ltd.

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Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry

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