TY - JOUR
T1 - Structural identification of mouse urinary metabolites of pterostilbene using liquid chromatography/tandem mass spectrometry
AU - Shao, Xi
AU - Chen, Xiaoxin
AU - Badmaev, Vladimir
AU - Ho, Chi-Tang
AU - Sang, Shengmin
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the present study, we identified nine novel mouse urinary pterostilbene metabolites, pterostilbene glucuronide, pterostilbene sulfate, mono-demethylated pterostilbene glucuronide, mono-demethylated pterostilbene sulfate, mono-hydroxylated pterostilbene, mono-hydroxylated pterostilbene glucuronide, mono-hydroxylated pterostilbene sulfate, and mono-hydroxylated pterostilbene glucuronide sulfate, using liquid chromatography/atmospheric pressure chemical ionization and electrospray ionization tandem mass spectrometry. The structures of these metabolites were confirmed by analyzing the MSn (n=1-3) spectra. To our knowledge, this is the first report of the identification of urinary metabolites of pterostilbene in mice. © 2010 John Wiley & Sons, Ltd.
AB - Pterostilbene, the dimethoxy derivative of resveratrol, has drawn much attention recently due to its potential beneficial health effects. The metabolic fate of pterostilbene, however, is not well understood. In the present study, we identified nine novel mouse urinary pterostilbene metabolites, pterostilbene glucuronide, pterostilbene sulfate, mono-demethylated pterostilbene glucuronide, mono-demethylated pterostilbene sulfate, mono-hydroxylated pterostilbene, mono-hydroxylated pterostilbene glucuronide, mono-hydroxylated pterostilbene sulfate, and mono-hydroxylated pterostilbene glucuronide sulfate, using liquid chromatography/atmospheric pressure chemical ionization and electrospray ionization tandem mass spectrometry. The structures of these metabolites were confirmed by analyzing the MSn (n=1-3) spectra. To our knowledge, this is the first report of the identification of urinary metabolites of pterostilbene in mice. © 2010 John Wiley & Sons, Ltd.
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U2 - 10.1002/rcm.4579
DO - 10.1002/rcm.4579
M3 - Article
SN - 0951-4198
VL - 24
SP - 1770
EP - 1778
JO - Rapid Communications in Mass Spectrometry
JF - Rapid Communications in Mass Spectrometry
IS - 12
ER -