Synthesis and Characterization of Alginate-Based Hydrogel Microbeads for Magnesium Release

Shalil Khanal; Udhab Adhikari; Nava P Rijal; Devdas M Pai; Jagannathan Sankar; Narayan Bhattarai

Synthesis and Characterization of Alginate-Based Hydrogel Microbeads for Magnesium Release

Shalil Khanal, Udhab Adhikari, Nava P Rijal, Devdas M Pai, Jagannathan Sankar, Narayan Bhattarai

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Magnesium injection is a suitable approach for replenishment of its ions (Mg⁺⁺) during neural or tissue injury and stroke to avoids risks associated with abnormally low level of Mg⁺⁺ in blood. In this study, alginate encapsulated magnesium sulfate microbeads were fabricated by the electrospraying technique for Mg⁺⁺ delivery. Microbeads were evaluated for particle size and surface morphology using inverted optical microscopy and scanning electron microscopy (SEM) respectively. Average particle size of 200-500 μm for hydrated and 50-200 μm for dry beads were observed. An in vitro release study of Mg⁺⁺ was performed; revealing a cumulative release of ∼50% within first 24 h. This strategy can potentially be useful for the targeted local delivery of magnesium at required concentrations and subsequently enhance the therapeutic efficacy of magnesium in treating tissue injury or stroke.

Original language	English
Title of host publication	ASME 2016 International Mechanical Engineering Congress and Exposition
Pages	V014T11A022--V014T11A022
State	Published - 2016

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@inproceedings{97256c8413f846a8a88f8e424320153b,

title = "Synthesis and Characterization of Alginate-Based Hydrogel Microbeads for Magnesium Release",

abstract = "Magnesium injection is a suitable approach for replenishment of its ions (Mg++) during neural or tissue injury and stroke to avoids risks associated with abnormally low level of Mg++ in blood. In this study, alginate encapsulated magnesium sulfate microbeads were fabricated by the electrospraying technique for Mg++ delivery. Microbeads were evaluated for particle size and surface morphology using inverted optical microscopy and scanning electron microscopy (SEM) respectively. Average particle size of 200-500 μm for hydrated and 50-200 μm for dry beads were observed. An in vitro release study of Mg++ was performed; revealing a cumulative release of ∼50\% within first 24 h. This strategy can potentially be useful for the targeted local delivery of magnesium at required concentrations and subsequently enhance the therapeutic efficacy of magnesium in treating tissue injury or stroke.",

author = "Shalil Khanal and Udhab Adhikari and Rijal, \{Nava P\} and Pai, \{Devdas M\} and Jagannathan Sankar and Narayan Bhattarai",

note = "Publisher Copyright: Copyright {\textcopyright} 2016 by ASME.",

year = "2016",

language = "English",

pages = "V014T11A022----V014T11A022",

booktitle = "ASME 2016 International Mechanical Engineering Congress and Exposition",

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TY - GEN

T1 - Synthesis and Characterization of Alginate-Based Hydrogel Microbeads for Magnesium Release

AU - Khanal, Shalil

AU - Adhikari, Udhab

AU - Rijal, Nava P

AU - Pai, Devdas M

AU - Sankar, Jagannathan

AU - Bhattarai, Narayan

PY - 2016

Y1 - 2016

N2 - Magnesium injection is a suitable approach for replenishment of its ions (Mg++) during neural or tissue injury and stroke to avoids risks associated with abnormally low level of Mg++ in blood. In this study, alginate encapsulated magnesium sulfate microbeads were fabricated by the electrospraying technique for Mg++ delivery. Microbeads were evaluated for particle size and surface morphology using inverted optical microscopy and scanning electron microscopy (SEM) respectively. Average particle size of 200-500 μm for hydrated and 50-200 μm for dry beads were observed. An in vitro release study of Mg++ was performed; revealing a cumulative release of ∼50% within first 24 h. This strategy can potentially be useful for the targeted local delivery of magnesium at required concentrations and subsequently enhance the therapeutic efficacy of magnesium in treating tissue injury or stroke.

AB - Magnesium injection is a suitable approach for replenishment of its ions (Mg++) during neural or tissue injury and stroke to avoids risks associated with abnormally low level of Mg++ in blood. In this study, alginate encapsulated magnesium sulfate microbeads were fabricated by the electrospraying technique for Mg++ delivery. Microbeads were evaluated for particle size and surface morphology using inverted optical microscopy and scanning electron microscopy (SEM) respectively. Average particle size of 200-500 μm for hydrated and 50-200 μm for dry beads were observed. An in vitro release study of Mg++ was performed; revealing a cumulative release of ∼50% within first 24 h. This strategy can potentially be useful for the targeted local delivery of magnesium at required concentrations and subsequently enhance the therapeutic efficacy of magnesium in treating tissue injury or stroke.

M3 - Conference contribution

SP - V014T11A022--V014T11A022

BT - ASME 2016 International Mechanical Engineering Congress and Exposition

ER -

Synthesis and Characterization of Alginate-Based Hydrogel Microbeads for Magnesium Release

Abstract

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