Synthesis of magnetite loaded fluorescence micelles of triblock copolymer

Bishnu Prasad Bastakoti; John Bentley; Destiny McLaurin; Shin-ichi Yusa; Surabhi Shaji; Nikhil R. Mucha; Dhananjay Kumar; Tansir Ahamad

doi:10.1016/j.molliq.2020.112785

Synthesis of magnetite loaded fluorescence micelles of triblock copolymer

Bishnu Prasad Bastakoti
, John Bentley
, Destiny McLaurin
, Shin-ichi Yusa
, Surabhi Shaji
, Nikhil R. Mucha
, Dhananjay Kumar
, Tansir Ahamad

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Magnetic micelles with fluorescence dyes were fabricated by self-assembly of triblock copolymer followed by in situ templated coprecipitation method. Nile red was encapsulated into the polystyrene core of the triblock copolymer confirmed by fluorescence measurement. The magnetic nanoparticles are selectively chemisorbed on the poly(acrylic acid) (PAA) shell of polymeric micelles due to ionic interaction between PAA and Fe ions. The negatively charged PAA also a platform to bind positively charged drug molecules. The hydrophilic poly(ethylene glycol) (PEG) corona stabilizes the micelles composites. The multifunctional polymeric micelles were well characterized by using different tools and techniques: dynamic light scattering, transmission electron microscope, UV–visible spectrophotometer, fluorescence spectroscope, and magnetometer.

Original language	English
Article number	112785
Journal	Journal of Molecular Liquids
Volume	305
Issue number	Issue
DOIs	https://doi.org/10.1016/j.molliq.2020.112785
State	Published - May 1 2020

Keywords

Block copolymer
Magnetic nanoparticle
Micelle
Nano carrier
Nile red
Self-assembly

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10.1016/j.molliq.2020.112785

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title = "Synthesis of magnetite loaded fluorescence micelles of triblock copolymer",

abstract = "Magnetic micelles with fluorescence dyes were fabricated by self-assembly of triblock copolymer followed by in situ templated coprecipitation method. Nile red was encapsulated into the polystyrene core of the triblock copolymer confirmed by fluorescence measurement. The magnetic nanoparticles are selectively chemisorbed on the poly(acrylic acid) (PAA) shell of polymeric micelles due to ionic interaction between PAA and Fe ions. The negatively charged PAA also a platform to bind positively charged drug molecules. The hydrophilic poly(ethylene glycol) (PEG) corona stabilizes the micelles composites. The multifunctional polymeric micelles were well characterized by using different tools and techniques: dynamic light scattering, transmission electron microscope, UV–visible spectrophotometer, fluorescence spectroscope, and magnetometer.",

keywords = "Block copolymer, Magnetic nanoparticle, Micelle, Nano carrier, Nile red, Self-assembly",

author = "Bastakoti, \{Bishnu Prasad\} and John Bentley and Destiny McLaurin and Shin-ichi Yusa and Surabhi Shaji and Mucha, \{Nikhil R.\} and Dhananjay Kumar and Tansir Ahamad",

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T1 - Synthesis of magnetite loaded fluorescence micelles of triblock copolymer

AU - Bastakoti, Bishnu Prasad

AU - Bentley, John

AU - McLaurin, Destiny

AU - Yusa, Shin-ichi

AU - Shaji, Surabhi

AU - Mucha, Nikhil R.

AU - Kumar, Dhananjay

AU - Ahamad, Tansir

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Magnetic micelles with fluorescence dyes were fabricated by self-assembly of triblock copolymer followed by in situ templated coprecipitation method. Nile red was encapsulated into the polystyrene core of the triblock copolymer confirmed by fluorescence measurement. The magnetic nanoparticles are selectively chemisorbed on the poly(acrylic acid) (PAA) shell of polymeric micelles due to ionic interaction between PAA and Fe ions. The negatively charged PAA also a platform to bind positively charged drug molecules. The hydrophilic poly(ethylene glycol) (PEG) corona stabilizes the micelles composites. The multifunctional polymeric micelles were well characterized by using different tools and techniques: dynamic light scattering, transmission electron microscope, UV–visible spectrophotometer, fluorescence spectroscope, and magnetometer.

AB - Magnetic micelles with fluorescence dyes were fabricated by self-assembly of triblock copolymer followed by in situ templated coprecipitation method. Nile red was encapsulated into the polystyrene core of the triblock copolymer confirmed by fluorescence measurement. The magnetic nanoparticles are selectively chemisorbed on the poly(acrylic acid) (PAA) shell of polymeric micelles due to ionic interaction between PAA and Fe ions. The negatively charged PAA also a platform to bind positively charged drug molecules. The hydrophilic poly(ethylene glycol) (PEG) corona stabilizes the micelles composites. The multifunctional polymeric micelles were well characterized by using different tools and techniques: dynamic light scattering, transmission electron microscope, UV–visible spectrophotometer, fluorescence spectroscope, and magnetometer.

KW - Block copolymer

KW - Magnetic nanoparticle

KW - Micelle

KW - Nano carrier

KW - Nile red

KW - Self-assembly

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U2 - 10.1016/j.molliq.2020.112785

DO - 10.1016/j.molliq.2020.112785

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SN - 0167-7322

VL - 305

JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

IS - Issue

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ER -

Synthesis of magnetite loaded fluorescence micelles of triblock copolymer

Abstract

Keywords

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