Thiabendazole

Thiabendazole (CAS 148-79-8) is a compound with benzimidazole group known for its uses as an anthelmintic and fungicide agent. Very recently, it is also reported to have the ability to slow tumor growth. It does not hydrolyze readily, nor it is metabolized in soil under aerobic or anaerobic conditions. Typically, birds and mammals can be exposed to such pesticide applied as foliar sprays or granulars by a variety of routes, including ingestion, dermal contact, and inhalation. This article reviews the general background, uses, environmental fate and behavior, toxicokinetics, exposure routes and pathways, toxicity, and carcinogenicity of thiabendazole. Further, its clinical management and exposure standards and guidelines are discussed.