Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum

Sheng-Min Sang; Min-Liang Zou; Xiong-Wen Zhang; Ai-Na Lao; Zhong-Liang Chen

doi:10.1080/10286020290019721

Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum

Sheng-Min Sang
, Min-Liang Zou
, Xiong-Wen Zhang
, Ai-Na Lao
, Zhong-Liang Chen

Family and Consumer Sciences

Materia Medica Chinese Acad. of Sci.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Tuberoside M (1), isolated from the seeds of Allium tuberosum, shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC50 value of 6.8 μg/ml. On the basis of spectral data and chemical reaction, its structure was established as (25S)-5β-spirostane-1β,3β-diol 3-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside.

Original language	English
Pages (from-to)	67-70
Number of pages	4
Journal	Journal of Asian Natural Products Research
Volume	4
Issue number	1
DOIs	https://doi.org/10.1080/10286020290019721
State	Published - Jan 1 2002

Keywords

Allium tuberosum
HL-60
Spirostanol saponin
Tuberoside M

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10.1080/10286020290019721

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abstract = "Tuberoside M (1), isolated from the seeds of Allium tuberosum, shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC50 value of 6.8 μg/ml. On the basis of spectral data and chemical reaction, its structure was established as (25S)-5β-spirostane-1β,3β-diol 3-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside.",

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AU - Sang, Sheng-Min

AU - Zou, Min-Liang

AU - Zhang, Xiong-Wen

AU - Lao, Ai-Na

AU - Chen, Zhong-Liang

PY - 2002/1/1

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AB - Tuberoside M (1), isolated from the seeds of Allium tuberosum, shows a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) with IC50 value of 6.8 μg/ml. On the basis of spectral data and chemical reaction, its structure was established as (25S)-5β-spirostane-1β,3β-diol 3-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranoside.

KW - Allium tuberosum

KW - HL-60

KW - Spirostanol saponin

KW - Tuberoside M

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Tuberoside M, a new cytotoxic spirostanol saponin from the seeds of Allium tuberosum

Abstract

Keywords

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